STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dcuRTwo-component response regulator; Similar to Escherichia coli transcriptional regulatory protein DcuR SW:DCUR_ECOLI (P39271) (239 aa) fasta scores: E(): 0, 88.3% id in 239 aa, and to Bacillus subtilis two-component response regulator CitT TR:O34534 (EMBL:Z99108) (226 aa) fasta scores: E(): 5.2e-19, 31.4% id in 226 aa. Contains helix-turn-helix motif, residues 179 to 200, score 1148 (+3.10 SD). (239 aa)    
Predicted Functional Partners:
dcuS
Two-component sensor kinase; Similar to Escherichia coli sensor protein DcuS SW:DCUS_ECOLI (P39272) (543 aa) fasta scores: E(): 0, 81.5% id in 542 aa, and to Bacillus subtilis two-component sensor histidine kinase CitS TR:O34427 (EMBL:Z99108) (542 aa) fasta scores: E(): 0, 30.5% id in 537 aa.
 
 0.999
dcuB
Anaerobic C4-dicarboxylate transporter; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
     
 0.854
citA
Sensor kinase cita; Similar to Klebsiella pneumoniae sensor kinase cita CITA SW:CITA_KLEPN (P52687) fasta scores: E(): 0, 83.7% id in 539 aa, and to Escherichia coli sensor kinase dpib DPIB OR CITA OR MPDB SW:DPIB_ECOLI (P77510; O54338) fasta scores: E(): 0, 42.1% id in 532 aa; Paralogue of E. coli DPIB_ECOLI; Fasta hit to DPIB_ECOLI (552 aa), 42% identity in 532 aa overlap.
 
 
 0.851
dpiB
Sensor kinase DpiB; Similar to Escherichia coli sensor kinase dpib dpib or cita or mpdB SW:DPIB_ECOLI (P77510; O54338) (552 aa) fasta scores: E(): 0, 87.0% id in 553 aa, and to Klebsiella pneumoniae sensor kinase CitA citA SW:CITA_KLEPN (P52687) (547 aa) fasta scores: E(): 0, 41.9% id in 537 aa; Orthologue of E. coli DPIB_ECOLI; Fasta hit to DPIB_ECOLI (552 aa), 87% identity in 553 aa overlap.
 
 
 0.842
pgtA
Similar to Salmonella typhimurium phosphoglycerate transport system transcriptional regulatory protein PgtA pgtA SW:PGTA_SALTY (P06184) (415 aa) fasta scores: E(): 0, 98.1% id in 415 aa.
  
   
 0.581
nrdI
NrdI protein; Probably involved in ribonucleotide reductase function.
      
 0.560
STY2472
Nitrate/nitrite response regulator protein NarP; Fasta hit to UHPA_ECOLI (196 aa), 37% identity in 195 aa overlap; Fasta hit to FIMZ_ECOLI (210 aa), 30% identity in 200 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 31% identity in 229 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 43% identity in 214 aa overlap; Fasta hit to UVRY_ECOLI (218 aa), 34% identity in 200 aa overlap; Orthologue of E. coli narP (NARP_ECOLI); Fasta hit to NARP_ECOLI (215 aa), 88% identity in 215 aa overlap.
  
   
 0.524
STY0058
LytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
      
 0.506
STY3096
Sensor protein; Similar to Escherichia coli sensor protein BarA involved in adaptive response SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 90.0% id in 921 aa; Orthologue of E. coli barA (BARA_ECOLI); Fasta hit to BARA_ECOLI (918 aa), 90% identity in 921 aa overlap.
     
 0.504
STY3507
Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap.
     
 0.504
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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