STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uxuRSimilar to Escherichia coli uxu operon transcriptional regulator uxuR SW:UXUR_ECOLI (P39161) (257 aa) fasta scores: E(): 0, 89.9% id in 257 aa, and to Erwinia chrysanthemi exu regulon transcriptional regulator exuR SW:EXUR_ERWCH (Q9X9E0) (259 aa) fasta scores: E(): 0, 46.9% id in 256 aa. Contains helix-turn-helix motif, residues 34 to 55, score 975(+2.51 SD); Fasta hit to PDHR_ECOLI (254 aa), 32% identity in 221 aa overlap; Fasta hit to EXUR_ECOLI (258 aa), 48% identity in 255 aa overlap; Orthologue of E. coli uxuR (UXUR_ECOLI); Fasta hit to UXUR_ECOLI (257 aa), 90% identity in 257 aa [...] (257 aa)    
Predicted Functional Partners:
STY3307
D-mannonate oxidoreductase; Fasta hit to YEIQ_ECOLI (488 aa), 57% identity in 470 aa overlap; Fasta hit to YDFI_ECOLI (486 aa), 57% identity in 485 aa overlap; Orthologue of E. coli uxuB (UXUB_ECOLI); Fasta hit to UXUB_ECOLI (486 aa), 80% identity in 484 aa overlap; Belongs to the mannitol dehydrogenase family.
 
   
 0.773
STY3888
Hypothetical 20.8 kDa protein in rbsr-rrsc intergenic region; Similar in part to Escherichia coli hypothetical protein YieP SW:YIEP_ECOLI (P31475) (181 aa) fasta scores: E(): 0, 83.5% id in 182 aa and to Streptomyces coelicolor putative gntr-famly transcriptional regulator scf37.08 TR:Q9RJZ3 (EMBL:AL133210) (246 aa) fasta scores: E(): 4.9e-17, 32.9% id in 216 aa; putative GntR-family transcriptional regulator.
  
     0.679
kdgR
Similar to Escherichia coli transcriptional regulator KdgR SW:KDGR_ECOLI (P76268) (263 aa) fasta scores: E(): 0, 96.2% id in 263 aa and to Pectobacterium carotovorum subspcartovorum KdgR TR:Q9RB24 (EMBL:AF135396) (263 aa) fasta scores: E(): 0, 86.7% id in 263 aa; Orthologue of E. coli KDGR_ECOLI; Fasta hit to KDGR_ECOLI (263 aa), 96% identity in 263 aa overlap.
  
  
 0.671
ygbP
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
      
 0.648
STY4268
Similar to Escherichia coli gluconate utilization system Gnt-I transcriptional repressor GntR SW:GNTR_ECOLI (P46860) (331 aa) fasta scores: E(): 0, 97.3% id in 331 aa, and to Escherichia coli L-idonate regulatory protein IdnR SW:IDNR_ECOLI (P39343) (332 aa) fasta scores: E(): 0, 45.8% id in 332 aa. Contains helix-turn-helix motif, residues 6 to 27, score 1844 (+5.47 SD).
  
 
 
 0.634
STY3214
Proline aminopeptidase II; Orthologue of E. coli pepP (AMPP_ECOLI); Fasta hit to AMPP_ECOLI (440 aa), 91% identity in 438 aa overlap.
      
 0.629
STY3537
Possible transcriptional regulator; Similar to Streptomyces coelicolor putative GntR-family transcriptional regulator scgd3.11C TR:Q9XA67 (EMBL:AL096822) (216 aa) fasta scores: E(): 7.4e-11, 33.2% id in 189 aa.
  
  
 0.578
kdgR-2
Probable global regulatory protein; Similar to Pectobacterium carotovorum subsp.cartovorum global regulatory protein kdgR TR:Q9RB25 (EMBL:AF135395) (263 aa) fasta scores: E(): 0.0059, 27.7% id in 173 aa and to Escherichia coli transcriptional regulator kdgR SW:KDGR_ECOLI (P76268; O07975) (263 aa) fasta scores: E(): 0.15, 25.5% id in 192 aa.
   
  
 0.491
nadR
Conserved hypothetical transcriptional regulator; Bifunctional protein. DNA binding, contains helix-turn-helix. Transporter, interacts with NcuC transporting NMN into the cell. Similar to Salmonella typhimurium transcriptional regulator NadR SW:NADR_SALTY (P24518) (409 aa) fasta scores: E(): 0, 98.8% id in 410 aa, and to Escherichia coli transcriptional regulator NadR SW:NADR_ECOLI (P27278; P76819) (410 aa) fasta scores: E(): 0, 94.6% id in 409 aa.
   
  
 0.490
STY3756
Similar to Escherichia coli hypothetical transcriptional regulator YijO SW:YIJO_ECOLI (P32677) (283 aa) fasta scores: E(): 0, 89.6% id in 278 aa and to Streptococcus mutans msm operon regulatory protein MsmR SW:MSMR_STRMU (Q00753) (278 aa) fasta scores: E(): 2.2e-08, 23.9% id in 259 aa; Fasta hit to YPDC_ECOLI (285 aa), 37% identity in 274 aa overlap.
   
  
 0.475
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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