node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_3843 | dcd | PFL_3843 | PFL_1261 | MazG nucleotide pyrophosphohydrolase domain protein; Identified by match to protein family HMM PF03819. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.901 |
PFL_3843 | ndk | PFL_3843 | PFL_4958 | MazG nucleotide pyrophosphohydrolase domain protein; Identified by match to protein family HMM PF03819. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.903 |
capB | dcd | PFL_1260 | PFL_1261 | Cold shock protein CapB; Identified by similarity to SP:P0A106; match to protein family HMM PF00313. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.568 |
dcd | PFL_3843 | PFL_1261 | PFL_3843 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | MazG nucleotide pyrophosphohydrolase domain protein; Identified by match to protein family HMM PF03819. | 0.901 |
dcd | capB | PFL_1261 | PFL_1260 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Cold shock protein CapB; Identified by similarity to SP:P0A106; match to protein family HMM PF00313. | 0.568 |
dcd | dut | PFL_1261 | PFL_6053 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.932 |
dcd | hisG | PFL_1261 | PFL_0928 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.546 |
dcd | mazG | PFL_1261 | PFL_4445 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside triphosphate pyrophosphohydrolase; Identified by similarity to SP:P0AEY3; match to protein family HMM PF01503; match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.921 |
dcd | ndk | PFL_1261 | PFL_4958 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.932 |
dcd | omlA | PFL_1261 | PFL_0823 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Outer membrane lipoprotein OmlA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.548 |
dcd | pyrE | PFL_1261 | PFL_6056 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.634 |
dcd | pyrG | PFL_1261 | PFL_1194 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.923 |
dcd | tmk | PFL_1261 | PFL_1801 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.546 |
dut | dcd | PFL_6053 | PFL_1261 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.932 |
dut | ndk | PFL_6053 | PFL_4958 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.942 |
dut | pyrE | PFL_6053 | PFL_6056 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.448 |
dut | tmk | PFL_6053 | PFL_1801 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.956 |
hisG | dcd | PFL_0928 | PFL_1261 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.546 |
hisG | pyrG | PFL_0928 | PFL_1194 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.402 |
mazG | dcd | PFL_4445 | PFL_1261 | Nucleoside triphosphate pyrophosphohydrolase; Identified by similarity to SP:P0AEY3; match to protein family HMM PF01503; match to protein family HMM PF03819; match to protein family HMM TIGR00444. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.921 |