| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PFL_4476 | apt | PFL_4476 | PFL_1909 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.408 |
| PFL_4476 | gmk | PFL_4476 | PFL_6061 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.938 |
| PFL_4476 | guaA | PFL_4476 | PFL_4939 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.679 |
| PFL_4476 | ndk | PFL_4476 | PFL_4958 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.940 |
| PFL_4476 | pyk_1 | PFL_4476 | PFL_1697 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Pyruvate kinase; Identified by similarity to SP:Q44473; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.911 |
| PFL_4476 | pyk_2 | PFL_4476 | PFL_4797 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Pyruvate kinase; Identified by similarity to SP:P21599; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.911 |
| PFL_4476 | spoT | PFL_4476 | PFL_6063 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.910 |
| PFL_4476 | xpt | PFL_4476 | PFL_6032 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.408 |
| PFL_5138 | apt | PFL_5138 | PFL_1909 | Putative hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.931 |
| PFL_5138 | gmk | PFL_5138 | PFL_6061 | Putative hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.949 |
| PFL_5138 | guaA | PFL_5138 | PFL_4939 | Putative hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.954 |
| PFL_5138 | xpt | PFL_5138 | PFL_6032 | Putative hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.930 |
| apt | PFL_4476 | PFL_1909 | PFL_4476 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.408 |
| apt | PFL_5138 | PFL_1909 | PFL_5138 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156. | 0.931 |
| apt | gmk | PFL_1909 | PFL_6061 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.955 |
| apt | guaA | PFL_1909 | PFL_4939 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.988 |
| apt | xpt | PFL_1909 | PFL_6032 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.911 |
| gmk | PFL_4476 | PFL_6061 | PFL_4476 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.938 |
| gmk | PFL_5138 | PFL_6061 | PFL_5138 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156. | 0.949 |
| gmk | apt | PFL_6061 | PFL_1909 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.955 |