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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
lp_0146NADH:flavin oxidoreductase/NADH oxidase. (369 aa)    
Predicted Functional Partners:
urdA
Fumarate reductase/succinate dehydrogenase,FAD-binding flavoprotein; Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino- histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.plantarum strain WCFS1, may contribute to the pathogenesis of type 2 diabetes by producing the [...]
 
  
 0.926
lp_3491
Fumarate reductase, flavoprotein subunit precursor.
 
  
 0.910
lp_1113
Fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
  
 0.908
adc
Acetoacetate decarboxylase.
 
    0.907
prs1
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
     
 0.811
lp_0163
acyl-CoA dehydrogenase domain protein.
  
 
 0.777
lp_3125
Fumarate reductase, flavoprotein subunit precursor.
 
  
 0.679
orf25
Hypothetical protein.
      
 0.611
kdtB
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
   
  
 0.534
lp_0149
Cobalt (or cobalamine) ABC transporter,ATP-binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
  
  
 0.455
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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