| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysE | glyA | lp_0254 | lp_2375 | Serine O-acetyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.860 |
| cysE | hom1 | lp_0254 | lp_2535 | Serine O-acetyltransferase. | Homoserine dehydrogenase. | 0.859 |
| cysE | hom2 | lp_0254 | lp_0571 | Serine O-acetyltransferase. | Homoserine dehydrogenase. | 0.847 |
| cysE | sdhA | lp_0254 | lp_0506 | Serine O-acetyltransferase. | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.911 |
| cysE | sdhB | lp_0254 | lp_0505 | Serine O-acetyltransferase. | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.911 |
| cysE | thrB | lp_0254 | lp_0572 | Serine O-acetyltransferase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.864 |
| cysE | trpA | lp_0254 | lp_1657 | Serine O-acetyltransferase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.818 |
| cysE | trpB | lp_0254 | lp_1658 | Serine O-acetyltransferase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.818 |
| dsdA | sdhA | lp_2776 | lp_0506 | D-serine dehydratase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.912 |
| dsdA | sdhB | lp_2776 | lp_0505 | D-serine dehydratase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.912 |
| glyA | cysE | lp_2375 | lp_0254 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine O-acetyltransferase. | 0.860 |
| glyA | sdhA | lp_2375 | lp_0506 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.951 |
| glyA | sdhB | lp_2375 | lp_0505 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.955 |
| glyA | trpA | lp_2375 | lp_1657 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.971 |
| glyA | trpB | lp_2375 | lp_1658 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.935 |
| hom1 | cysE | lp_2535 | lp_0254 | Homoserine dehydrogenase. | Serine O-acetyltransferase. | 0.859 |
| hom1 | hom2 | lp_2535 | lp_0571 | Homoserine dehydrogenase. | Homoserine dehydrogenase. | 0.912 |
| hom1 | sdhA | lp_2535 | lp_0506 | Homoserine dehydrogenase. | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.824 |
| hom1 | sdhB | lp_2535 | lp_0505 | Homoserine dehydrogenase. | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.824 |
| hom1 | thrB | lp_2535 | lp_0572 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.990 |