STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldhL1L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (320 aa)    
Predicted Functional Partners:
ldhD
D-lactate dehydrogenase.
  
 0.990
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.987
pgi
Glucose-6-phosphate isomerase.
  
 
 0.958
mleS
Malolactic enzyme; Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. Catalyzes the decarboxylation of L-malate to L-lactate. Belongs to the malic enzymes family.
  
 0.957
larA
Lactate racemization operon protein LarA; Catalyzes the interconversion between the D- and L-isomers of lactate. May act as a rescue enzyme to ensure D-lactate production in physiological conditions where its production by the D-lactate dehydrogenase LdhD is not sufficient. D-Lactate is absolutely required for growth of L.plantarum and is an essential component of the cell wall peptidoglycan in this species, where it is incorporated as the last residue of the muramoyl-pentadepsipeptide peptidoglycan precursor; its incorporation confers high level of vancomycin resistance.
     
 0.951
pycA
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.941
mae
Malic enzyme, NAD-dependent.
  
 0.930
pflF
Formate C-acetyltransferase.
   
 
 0.927
pflB
Formate C-acetyltransferase.
   
 
 0.926
pdhB
Pyruvate dehydrogenase complex, E1 component,beta subunit.
   
 0.925
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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