STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lp_0952Fumarate reductase, flavoprotein subunit precursor. (629 aa)    
Predicted Functional Partners:
lp_3491
Fumarate reductase, flavoprotein subunit precursor.
    0.758
lp_0951
Transcription regulator, LysR family; Belongs to the LysR transcriptional regulatory family.
 
    0.750
lp_2733
NADPH-dependent FMN reductase family protein.
 
    0.732
lp_1424
NADPH-dependent FMN reductase family protein.
 
    0.722
urdA
Fumarate reductase/succinate dehydrogenase,FAD-binding flavoprotein; Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino- histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.plantarum strain WCFS1, may contribute to the pathogenesis of type 2 diabetes by producing the [...]
 
   
0.552
lp_0060
Short-chain dehydrogenase/oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
    0.481
lp_0063
Hypothetical protein.
  
    0.470
apbE2
Thiamin biosynthesis lipoprotein ApbE; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
 
  
 0.416
lp_3244
NADPH-dependent FMN reductase family protein.
 
    0.413
lp_2732
NADPH-dependent FMN reductase family protein.
 
    0.409
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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