STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glpF4Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. (238 aa)    
Predicted Functional Partners:
larR
Transcription regulator, Crp/FNR family; Positive transcriptional regulator that is absolutely required for the expression of lactate racemase (Lar) activity. Controls Lar expression by sensing the L-/D-lactate ration. Binds to a 16-bp palindromic sequence (Lar box motif) that is present in the larR- larA intergenic region, allowing transcription of the larABCDE operon.
 
 
 0.884
glpD
Glycerol-3-phosphate dehydrogenase,FAD-dependent.
  
  
 0.743
larA
Lactate racemization operon protein LarA; Catalyzes the interconversion between the D- and L-isomers of lactate. May act as a rescue enzyme to ensure D-lactate production in physiological conditions where its production by the D-lactate dehydrogenase LdhD is not sufficient. D-Lactate is absolutely required for growth of L.plantarum and is an essential component of the cell wall peptidoglycan in this species, where it is incorporated as the last residue of the muramoyl-pentadepsipeptide peptidoglycan precursor; its incorporation confers high level of vancomycin resistance.
 
  
 0.736
glpF6
Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.632
larQ
Cobalt ABC transporter, permease protein; Probable transmembrane component of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import.
  
   
 0.624
ndk
Nucleoside-diphosphate kinase; Belongs to the NDK family.
  
 
 0.606
larO
Cobalt ABC transporter, ATP-binding protein; Probable ATP-binding component of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import. LarO is presumably responsible for energy coupling to the transport system.
      
 0.561
lysP
Lysine transport protein.
   
  
 0.559
kup1
Potassium uptake protein; Transport of potassium into the cell; Belongs to the HAK/KUP transporter (TC 2.A.72) family.
      
 0.555
gykA
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
  
 
 0.541
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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