| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glpD | glpF4 | lp_0371 | lp_1175 | Glycerol-3-phosphate dehydrogenase,FAD-dependent. | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | 0.743 |
| glpD | glpF6 | lp_0371 | lp_3463 | Glycerol-3-phosphate dehydrogenase,FAD-dependent. | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.625 |
| glpD | gykA | lp_0371 | lp_0834 | Glycerol-3-phosphate dehydrogenase,FAD-dependent. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.980 |
| glpF4 | glpD | lp_1175 | lp_0371 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Glycerol-3-phosphate dehydrogenase,FAD-dependent. | 0.743 |
| glpF4 | glpF6 | lp_1175 | lp_3463 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.632 |
| glpF4 | gykA | lp_1175 | lp_0834 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.541 |
| glpF4 | kup1 | lp_1175 | lp_0525 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Potassium uptake protein; Transport of potassium into the cell; Belongs to the HAK/KUP transporter (TC 2.A.72) family. | 0.555 |
| glpF4 | larA | lp_1175 | lp_0104 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Lactate racemization operon protein LarA; Catalyzes the interconversion between the D- and L-isomers of lactate. May act as a rescue enzyme to ensure D-lactate production in physiological conditions where its production by the D-lactate dehydrogenase LdhD is not sufficient. D-Lactate is absolutely required for growth of L.plantarum and is an essential component of the cell wall peptidoglycan in this species, where it is incorporated as the last residue of the muramoyl-pentadepsipeptide peptidoglycan precursor; its incorporation confers high level of vancomycin resistance. | 0.736 |
| glpF4 | larO | lp_1175 | lp_0100 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Cobalt ABC transporter, ATP-binding protein; Probable ATP-binding component of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import. LarO is presumably responsible for energy coupling to the transport system. | 0.561 |
| glpF4 | larQ | lp_1175 | lp_0101 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Cobalt ABC transporter, permease protein; Probable transmembrane component of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import. | 0.624 |
| glpF4 | larR | lp_1175 | lp_0103 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Transcription regulator, Crp/FNR family; Positive transcriptional regulator that is absolutely required for the expression of lactate racemase (Lar) activity. Controls Lar expression by sensing the L-/D-lactate ration. Binds to a 16-bp palindromic sequence (Lar box motif) that is present in the larR- larA intergenic region, allowing transcription of the larABCDE operon. | 0.884 |
| glpF4 | lysP | lp_1175 | lp_1008 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Lysine transport protein. | 0.559 |
| glpF4 | ndk | lp_1175 | lp_0242 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.606 |
| glpF6 | glpD | lp_3463 | lp_0371 | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | Glycerol-3-phosphate dehydrogenase,FAD-dependent. | 0.625 |
| glpF6 | glpF4 | lp_3463 | lp_1175 | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | 0.632 |
| glpF6 | gykA | lp_3463 | lp_0834 | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.531 |
| glpF6 | ndk | lp_3463 | lp_0242 | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.512 |
| gykA | glpD | lp_0834 | lp_0371 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Glycerol-3-phosphate dehydrogenase,FAD-dependent. | 0.980 |
| gykA | glpF4 | lp_0834 | lp_1175 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | 0.541 |
| gykA | glpF6 | lp_0834 | lp_3463 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Glycerol uptake facilitator protein; Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.531 |