STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lp_1422Transcription regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (315 aa)    
Predicted Functional Partners:
urdA
Fumarate reductase/succinate dehydrogenase,FAD-binding flavoprotein; Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino- histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.plantarum strain WCFS1, may contribute to the pathogenesis of type 2 diabetes by producing the [...]
 
  
 0.860
lp_2689
Transcription regulator, LysR family; Belongs to the LysR transcriptional regulatory family.
  
    0.694
lp_1685
Transcription regulator, LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.661
lp_2842
Transcription regulator, LysR family; Belongs to the LysR transcriptional regulatory family.
  
    0.626
lp_3024
Transcription regulator, LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.547
mleR1
Malolactic regulator, LysR family; Belongs to the LysR transcriptional regulatory family.
  
    0.493
lp_1420
Carboxyterminal processing proteinase, S41 family, membrane-anchored.
     
 0.460
lp_0675
Prophage P1 protein 52, endolysin.
  
     0.433
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.