| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA1 | birA2 | lp_0337 | lp_0854 | biotin-[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | biotin-[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.932 |
| birA1 | nrdR | lp_0337 | lp_1511 | biotin-[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Transcription regulator NrdR, ATP cone family; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.854 |
| birA2 | birA1 | lp_0854 | lp_0337 | biotin-[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | biotin-[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.932 |
| birA2 | nrdR | lp_0854 | lp_1511 | biotin-[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Transcription regulator NrdR, ATP cone family; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.835 |
| cmk | nrdF | lp_1883 | lp_0692 | Cytidylate kinase. | Ribonucleoside-diphosphate reductase, beta chain. | 0.933 |
| cmk | nrdR | lp_1883 | lp_1511 | Cytidylate kinase. | Transcription regulator NrdR, ATP cone family; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.726 |
| cmk | polA | lp_1883 | lp_1508 | Cytidylate kinase. | DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.503 |
| coaE | dnaB | lp_1510 | lp_1512 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Replication initiation and membrane attachment protein DnaB. | 0.808 |
| coaE | dnaI | lp_1510 | lp_1513 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Primosomal protein DnaI. | 0.784 |
| coaE | fpg | lp_1510 | lp_1509 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.997 |
| coaE | nrdR | lp_1510 | lp_1511 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Transcription regulator NrdR, ATP cone family; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.832 |
| coaE | polA | lp_1510 | lp_1508 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.956 |
| dnaB | coaE | lp_1512 | lp_1510 | Replication initiation and membrane attachment protein DnaB. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.808 |
| dnaB | dnaI | lp_1512 | lp_1513 | Replication initiation and membrane attachment protein DnaB. | Primosomal protein DnaI. | 0.977 |
| dnaB | fpg | lp_1512 | lp_1509 | Replication initiation and membrane attachment protein DnaB. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.907 |
| dnaB | nrdR | lp_1512 | lp_1511 | Replication initiation and membrane attachment protein DnaB. | Transcription regulator NrdR, ATP cone family; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.946 |
| dnaB | polA | lp_1512 | lp_1508 | Replication initiation and membrane attachment protein DnaB. | DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.813 |
| dnaI | coaE | lp_1513 | lp_1510 | Primosomal protein DnaI. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.784 |
| dnaI | dnaB | lp_1513 | lp_1512 | Primosomal protein DnaI. | Replication initiation and membrane attachment protein DnaB. | 0.977 |
| dnaI | fpg | lp_1513 | lp_1509 | Primosomal protein DnaI. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.854 |