STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lp_1860Flavin monooxygenase, luciferase-like monooxygenase family. (352 aa)    
Predicted Functional Partners:
lp_1859
NADP oxidoreductase coenzyme, F420-dependent.
 
  
 0.972
dltA
D-alanine-poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to t [...]
   
 
 0.693
npsB
Non-ribosomal peptide synthetase NpsB.
   
 
 0.601
lp_2076
Nitrate/sulfonate/bicarbonate ABC transporter,ATP-binding protein.
  
  
 0.544
lp_2077
Nitrate/sulfonate/bicarbonate ABC transporter,permease protein.
  
  
 0.535
urdA
Fumarate reductase/succinate dehydrogenase,FAD-binding flavoprotein; Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino- histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.plantarum strain WCFS1, may contribute to the pathogenesis of type 2 diabetes by producing the [...]
  
 
 0.484
lp_3491
Fumarate reductase, flavoprotein subunit precursor.
  
 
 0.473
mrr
Mrr restriction system protein.
  
    0.466
lp_0244
NADPH-dependent FMN reductase family protein.
  
 
 0.427
lp_1863
Drug resistance transport protein, major facilitator subfamily (MFS), EmrB/QacA subfamily.
       0.422
Your Current Organism:
Lactobacillus plantarum
NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.