node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | guaB | lp_0914 | lp_3194 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Inosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.999 |
guaA | hprT | lp_0914 | lp_0546 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.975 |
guaA | lp_2265 | lp_0914 | lp_2265 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | CBS domain-containing protein. | 0.849 |
guaA | ndk | lp_0914 | lp_0242 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.528 |
guaA | xpt | lp_0914 | lp_1139 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.985 |
guaA | xtp1 | lp_0914 | lp_2267 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.963 |
guaB | guaA | lp_3194 | lp_0914 | Inosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | hprT | lp_3194 | lp_0546 | Inosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.918 |
guaB | xpt | lp_3194 | lp_1139 | Inosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.921 |
guaB | xtp1 | lp_3194 | lp_2267 | Inosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.921 |
hprT | guaA | lp_0546 | lp_0914 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.975 |
hprT | guaB | lp_0546 | lp_3194 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine 5'-monophosphate (IMP) dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.918 |
hprT | ndk | lp_0546 | lp_0242 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.404 |
hprT | xpt | lp_0546 | lp_1139 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.932 |
hprT | xtp1 | lp_0546 | lp_2267 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.908 |
lp_1196 | xtp1 | lp_1196 | lp_2267 | Integrase/recombinase. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.643 |
lp_2265 | guaA | lp_2265 | lp_0914 | CBS domain-containing protein. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.849 |
lp_2265 | lp_2266 | lp_2265 | lp_2266 | CBS domain-containing protein. | Phosphoesterase. | 0.918 |
lp_2265 | lp_2269 | lp_2265 | lp_2269 | CBS domain-containing protein. | Hypothetical protein, DUF2507 family. | 0.676 |
lp_2265 | murI | lp_2265 | lp_2268 | CBS domain-containing protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.641 |