rrp8 protein (Lactobacillus plantarum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

rrp8

Two-component system response regulator. (249 aa)

Predicted Functional Partners:

lp_2664

0.930

pltK

0.871

lamK

0.853

hpk9

0.798

lamC

0.783

lamR

0.757

lamA

0.748

plnB

0.725

plnD

0.711

lp_2485

0.669

Your Current Organism:

Lactobacillus plantarum

NCBI taxonomy Id: 220668
Other names: L. plantarum WCFS1, Lactobacillus plantarum WCFS1, Lactobacillus plantarum str. WCFS1, Lactobacillus plantarum strain WCFS1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hpk9	lamA	lp_3063	lp_3580	Two-component system histidine protein kinase; sensor protein.	Two-component system response regulator; accesory gene regulator protein A.	0.923
hpk9	lamC	lp_3063	lp_3581	Two-component system histidine protein kinase; sensor protein.	Two-component system histidine protein kinase; sensor protein.	0.523
hpk9	lamK	lp_3063	lp_3088	Two-component system histidine protein kinase; sensor protein.	Two-component system histidine protein kinase; sensor protein.	0.534
hpk9	lamR	lp_3063	lp_3087	Two-component system histidine protein kinase; sensor protein.	Two-component system response regulator.	0.924
hpk9	lp_2485	lp_3063	lp_2485	Two-component system histidine protein kinase; sensor protein.	Hypothetical protein, DUF1975 family.	0.653
hpk9	plnB	lp_3063	lp_0416	Two-component system histidine protein kinase; sensor protein.	Two-componet system histidine protein kinase PlnB; sensor protein.	0.491
hpk9	plnD	lp_3063	lp_0418	Two-component system histidine protein kinase; sensor protein.	Two-component response regulator PlnD,repressor.	0.921
hpk9	pltK	lp_3063	lp_1355	Two-component system histidine protein kinase; sensor protein.	Two-component system histidine protein kinase; sensor protein.	0.523
hpk9	rrp8	lp_3063	lp_2665	Two-component system histidine protein kinase; sensor protein.	Two-component system response regulator.	0.798
lamA	hpk9	lp_3580	lp_3063	Two-component system response regulator; accesory gene regulator protein A.	Two-component system histidine protein kinase; sensor protein.	0.923
lamA	lamC	lp_3580	lp_3581	Two-component system response regulator; accesory gene regulator protein A.	Two-component system histidine protein kinase; sensor protein.	0.986
lamA	lamK	lp_3580	lp_3088	Two-component system response regulator; accesory gene regulator protein A.	Two-component system histidine protein kinase; sensor protein.	0.954
lamA	plnB	lp_3580	lp_0416	Two-component system response regulator; accesory gene regulator protein A.	Two-componet system histidine protein kinase PlnB; sensor protein.	0.922
lamA	pltK	lp_3580	lp_1355	Two-component system response regulator; accesory gene regulator protein A.	Two-component system histidine protein kinase; sensor protein.	0.953
lamA	rrp8	lp_3580	lp_2665	Two-component system response regulator; accesory gene regulator protein A.	Two-component system response regulator.	0.748
lamC	hpk9	lp_3581	lp_3063	Two-component system histidine protein kinase; sensor protein.	Two-component system histidine protein kinase; sensor protein.	0.523
lamC	lamA	lp_3581	lp_3580	Two-component system histidine protein kinase; sensor protein.	Two-component system response regulator; accesory gene regulator protein A.	0.986
lamC	lamR	lp_3581	lp_3087	Two-component system histidine protein kinase; sensor protein.	Two-component system response regulator.	0.967
lamC	plnB	lp_3581	lp_0416	Two-component system histidine protein kinase; sensor protein.	Two-componet system histidine protein kinase PlnB; sensor protein.	0.614
lamC	plnD	lp_3581	lp_0418	Two-component system histidine protein kinase; sensor protein.	Two-component response regulator PlnD,repressor.	0.970

page 1 of 4

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098719

Sodium ion import across plasma membrane

5 of 10

3.04

5.3

1.66e-10

GO:0051453

Regulation of intracellular pH

5 of 65

2.23

3.21

3.32e-07

GO:0014067

Negative regulation of phosphatidylinositol 3-kinase signaling

3 of 6

3.04

2.96

4.14e-06

GO:0072657

Protein localization to membrane

4 of 333

1.42

1.07

0.0030

GO:0072659

Protein localization to plasma membrane

3 of 145

1.66

1.01

0.0082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015385

Sodium:proton antiporter activity

5 of 11

3.0

5.46

7.96e-11

GO:0015386

Potassium:proton antiporter activity

5 of 14

2.89

5.34

1.06e-10

GO:0043495

Protein-membrane adaptor activity

3 of 26

2.4

2.32

4.04e-05

GO:0008013

Beta-catenin binding

3 of 58

2.05

1.77

0.00032

GO:0030674

Protein-macromolecule adaptor activity

4 of 304

1.46

1.25

0.00098

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098858

Actin-based cell projection

3 of 138

1.68

0.93

0.0129

GO:0016324

Apical plasma membrane

3 of 210

1.5

0.72

0.0330

GO:0005886

Plasma membrane

10 of 5545

0.6

0.44

0.0046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32013

Mixed, incl. Sodium ion import across plasma membrane, and Positive regulation of early endosome to late endosome transport

9 of 18

3.04

11.41

1.68e-22

CL:32014

Mixed, incl. Positive regulation of early endosome to late endosome transport, and Negative regulation of phosphatidylinositol 3-kinase signaling

6 of 12

3.04

7.2

3.87e-14

CL:32016

EBP50, C-terminal, and Positive regulation of early endosome to late endosome transport

3 of 5

3.12

2.98

3.89e-06

CL:32037

Mixed, incl. Regulatory region of Na+/H+ exchanger NHE binds to calmodulin, and Cellular response to acidic pH

3 of 6

3.04

2.92

4.86e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

5 of 343

1.5

1.66

5.13e-05

map04260

Cardiac muscle contraction

3 of 176

1.57

1.03

0.0062

map04371

Apelin signaling pathway

3 of 230

1.46

0.92

0.0091

map04530

Tight junction

3 of 275

1.38

0.86

0.0114

map04261

Adrenergic signaling in cardiomyocytes

3 of 283

1.37

0.85

0.0114

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425986

Sodium/Proton exchangers

5 of 11

3.0

5.56

4.97e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 191

1.76

2.14

1.25e-05

MAP-425407

SLC-mediated transmembrane transport

5 of 431

1.4

1.3

0.00045

MAP-2160916

Hyaluronan uptake and degradation

2 of 14

2.5

1.11

0.0094

MAP-2142845

Hyaluronan metabolism

2 of 29

2.18

0.83

0.0292

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005902

Microvillus

3 of 33

2.3

1.65

0.00077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

5 of 13

2.93

5.71

2.17e-11

KW-0739

Sodium transport

5 of 23

2.68

5.18

1.24e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

5 of 14

2.89

5.22

1.86e-10

PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

4 of 4

3.34

4.8

1.93e-09

PF09007

EBP50, C-terminal

2 of 2

3.34

1.69

0.00089

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