| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| czcD2 | glpF4 | lp_3288 | lp_1175 | Cation (cobalt-zinc-cadmium) efflux protein. | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | 0.533 |
| czcD2 | infC | lp_3288 | lp_1515 | Cation (cobalt-zinc-cadmium) efflux protein. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.548 |
| czcD2 | lp_3286 | lp_3288 | lp_3286 | Cation (cobalt-zinc-cadmium) efflux protein. | Hypothetical membrane protein, hemolysin III family. | 0.505 |
| czcD2 | lp_3287 | lp_3288 | lp_3287 | Cation (cobalt-zinc-cadmium) efflux protein. | Transcription regulator, ArsR family. | 0.598 |
| czcD2 | ndk | lp_3288 | lp_0242 | Cation (cobalt-zinc-cadmium) efflux protein. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.556 |
| czcD2 | pflE | lp_3288 | lp_2596 | Cation (cobalt-zinc-cadmium) efflux protein. | Formate acetyltransferase activating enzyme. | 0.715 |
| czcD2 | pps | lp_3288 | lp_1912 | Cation (cobalt-zinc-cadmium) efflux protein. | Phosphoenolpyruvate synthase (pyruvate phosphate dikinase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.550 |
| czcD2 | tkt1A | lp_3288 | lp_0489 | Cation (cobalt-zinc-cadmium) efflux protein. | Transketolase, thiamine diphosphate binding domain. | 0.503 |
| czcD2 | tkt2 | lp_3288 | lp_1083 | Cation (cobalt-zinc-cadmium) efflux protein. | Transketolase; Belongs to the transketolase family. | 0.503 |
| czcD2 | tkt3 | lp_3288 | lp_3135 | Cation (cobalt-zinc-cadmium) efflux protein. | Transketolase; Belongs to the transketolase family. | 0.547 |
| glpF4 | czcD2 | lp_1175 | lp_3288 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Cation (cobalt-zinc-cadmium) efflux protein. | 0.533 |
| glpF4 | ndk | lp_1175 | lp_0242 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.606 |
| glpF4 | pflE | lp_1175 | lp_2596 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Formate acetyltransferase activating enzyme. | 0.540 |
| glpF4 | pps | lp_1175 | lp_1912 | Glycerol uptake facilitator protein; Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. | Phosphoenolpyruvate synthase (pyruvate phosphate dikinase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.449 |
| infC | czcD2 | lp_1515 | lp_3288 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Cation (cobalt-zinc-cadmium) efflux protein. | 0.548 |
| infC | ndk | lp_1515 | lp_0242 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Nucleoside-diphosphate kinase; Belongs to the NDK family. | 0.498 |
| infC | pflE | lp_1515 | lp_2596 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Formate acetyltransferase activating enzyme. | 0.562 |
| infC | pps | lp_1515 | lp_1912 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Phosphoenolpyruvate synthase (pyruvate phosphate dikinase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.465 |
| infC | tkt1A | lp_1515 | lp_0489 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Transketolase, thiamine diphosphate binding domain. | 0.405 |
| infC | tkt2 | lp_1515 | lp_1083 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Transketolase; Belongs to the transketolase family. | 0.416 |