| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpL | clpP | lp_3583 | lp_0786 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.921 |
| clpL | clpX | lp_3583 | lp_2116 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.832 |
| clpL | ctsR | lp_3583 | lp_1018 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | Transcription repressor of class III stress genes; Binds to the ftsH promoter region, leading to repression of its expression. | 0.830 |
| clpL | dnaJ | lp_3583 | lp_2026 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.774 |
| clpL | dnaK | lp_3583 | lp_2027 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | Chaperone, heat shock protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.941 |
| clpL | groEL | lp_3583 | lp_0728 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | GroEL chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.792 |
| clpL | groES | lp_3583 | lp_0727 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | GroES co-chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.793 |
| clpL | grpE | lp_3583 | lp_2028 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.815 |
| clpL | hslU | lp_3583 | lp_1845 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | ATP-dependent Hsl protease, ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.760 |
| clpL | hsp3 | lp_3583 | lp_3352 | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | Small heat shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.747 |
| clpP | clpL | lp_0786 | lp_3583 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family. | 0.921 |
| clpP | clpX | lp_0786 | lp_2116 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.999 |
| clpP | ctsR | lp_0786 | lp_1018 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcription repressor of class III stress genes; Binds to the ftsH promoter region, leading to repression of its expression. | 0.888 |
| clpP | dnaJ | lp_0786 | lp_2026 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.817 |
| clpP | dnaK | lp_0786 | lp_2027 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone, heat shock protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.951 |
| clpP | groEL | lp_0786 | lp_0728 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | GroEL chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.971 |
| clpP | groES | lp_0786 | lp_0727 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | GroES co-chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.971 |
| clpP | grpE | lp_0786 | lp_2028 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.910 |
| clpP | hslU | lp_0786 | lp_1845 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Hsl protease, ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.739 |
| clpP | hsp3 | lp_0786 | lp_3352 | Endopeptidase Clp, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Small heat shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.679 |
