node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OB0046 | OB1507 | gene:10732208 | gene:10733747 | methionine-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.635 |
OB0046 | fmt | gene:10732208 | gene:10733746 | methionine-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.937 |
OB0046 | glyA | gene:10732208 | gene:10735237 | methionine-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.553 |
OB0046 | nusB | gene:10732208 | gene:10734121 | methionine-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | Transcriptional terminator; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.550 |
OB0748 | OB1904 | gene:10732969 | gene:10734144 | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T-protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
OB0748 | dfrA | gene:10732969 | gene:10733979 | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.912 |
OB0748 | fmt | gene:10732969 | gene:10733746 | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.932 |
OB0748 | folD | gene:10732969 | gene:10734120 | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+) : methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.975 |
OB0748 | glyA | gene:10732969 | gene:10735237 | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
OB1507 | OB0046 | gene:10733747 | gene:10732208 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | methionine-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.635 |
OB1507 | OB1508 | gene:10733747 | gene:10733748 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Hypothetical conserved protein; CDS_ID OB1508. | 0.984 |
OB1507 | fmt | gene:10733747 | gene:10733746 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.999 |
OB1507 | folD | gene:10733747 | gene:10734120 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Methylenetetrahydrofolate dehydrogenase (NADP+) : methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.810 |
OB1507 | glyA | gene:10733747 | gene:10735237 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.429 |
OB1507 | priA | gene:10733747 | gene:10733745 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Primosomal replication factor Y; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.821 |
OB1508 | OB1507 | gene:10733748 | gene:10733747 | Hypothetical conserved protein; CDS_ID OB1508. | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.984 |
OB1508 | OB1904 | gene:10733748 | gene:10734144 | Hypothetical conserved protein; CDS_ID OB1508. | Aminomethyltransferase (glycine cleavage system T-protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.827 |
OB1508 | fmt | gene:10733748 | gene:10733746 | Hypothetical conserved protein; CDS_ID OB1508. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.917 |
OB1508 | priA | gene:10733748 | gene:10733745 | Hypothetical conserved protein; CDS_ID OB1508. | Primosomal replication factor Y; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.689 |
OB1904 | OB0748 | gene:10734144 | gene:10732969 | Aminomethyltransferase (glycine cleavage system T-protein); The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.933 |