node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OB2345 | OB2373 | gene:10734596 | gene:10734624 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.902 |
OB2345 | guaA | gene:10734596 | gene:10732937 | Purine nucleoside phosphorylase; CDS_ID OB2345. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.461 |
OB2345 | pdp | gene:10734596 | gene:10734084 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Pyrimidine-nucleoside phosphorylase; CDS_ID OB1844. | 0.953 |
OB2345 | pnp | gene:10734596 | gene:10734085 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.932 |
OB2345 | pyrR | gene:10734596 | gene:10733727 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Uracil phosphoribosyltransferase (transcriptional attenuation of the pyrimidine operon); Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.900 |
OB2345 | upp | gene:10734596 | gene:10735236 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.914 |
OB2373 | OB2345 | gene:10734624 | gene:10734596 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Purine nucleoside phosphorylase; CDS_ID OB2345. | 0.902 |
OB2373 | guaA | gene:10734624 | gene:10732937 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.918 |
OB2373 | pdp | gene:10734624 | gene:10734084 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Pyrimidine-nucleoside phosphorylase; CDS_ID OB1844. | 0.907 |
OB2373 | pnp | gene:10734624 | gene:10734085 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.915 |
OB2373 | pyrF | gene:10734624 | gene:10733734 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.902 |
OB2373 | pyrR | gene:10734624 | gene:10733727 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Uracil phosphoribosyltransferase (transcriptional attenuation of the pyrimidine operon); Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.900 |
OB2373 | smbA | gene:10734624 | gene:10733828 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
OB2373 | udk | gene:10734624 | gene:10734249 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Uridine kinase; CDS_ID OB2003. | 0.909 |
OB2373 | upp | gene:10734624 | gene:10735236 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.903 |
glyA | guaA | gene:10735237 | gene:10732937 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.587 |
glyA | smbA | gene:10735237 | gene:10733828 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.403 |
glyA | upp | gene:10735237 | gene:10735236 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.903 |
guaA | OB2345 | gene:10732937 | gene:10734596 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Purine nucleoside phosphorylase; CDS_ID OB2345. | 0.461 |
guaA | OB2373 | gene:10732937 | gene:10734624 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.918 |