STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
sdhA
Succinate dehydrogenase flavoprotein subunit; CDS_ID OB2113.
 
 0.995
sdhB
Succinate dehydrogenase iron-sulfur protein; CDS_ID OB2112.
 
 0.994
sdhC
Succinate dehydrogenase cytochrome b-556 subunit; CDS_ID OB2114.
 
 
 0.987
OB1090
2-oxoglutarate dehydrogenase E2 subunit (dihydrolipoamide S-succinyltransferase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.974
OB1089
Oxoglutarate dehydrogenase E1 subunit (alpha-ketoglutarte dehydrogenase); E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
 
 0.964
OB2875
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); CDS_ID OB2875.
 
 0.945
OB3115
Coenzyme A transferase; CDS_ID OB3115.
   
 0.939
pdhC
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); CDS_ID OB1414.
  
 0.938
OB2267
Carboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
    
 0.926
Your Current Organism:
Oceanobacillus iheyensis
NCBI taxonomy Id: 221109
Other names: O. iheyensis HTE831, Oceanobacillus iheyensis HTE831, Oceanobacillus iheyensis str. HTE831, Oceanobacillus iheyensis strain HTE831, marine firmicute HTE831
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.