SFB91252.1 protein (Algibacter lectus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

SFB91252.1

Hypothetical protein. (230 aa)

Predicted Functional Partners:

SFB91211.1

0.952

SFB91168.1

0.915

SFB91291.1

0.912

SFB91333.1

0.827

SFB89948.1

0.815

SFB89873.1

0.783

SFB92970.1

0.766

SFB90931.1

0.746

SFB90885.1

0.743

SFB89825.1

0.742

Your Current Organism:

Algibacter lectus

NCBI taxonomy Id: 221126
Other names: A. lectus, Algibacter lectus Nedashkovskaya et al. 2004, Bacteroidetes bacterium KMM 3902, Bacteroidetes bacterium KMM 3914, DSM 15365, JCM 21761, KCTC 12103, KMM 3902

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFB89825.1	SFB89873.1	SAMN04489722_101208	SAMN04489722_101209	RteC protein.	Helix-turn-helix domain-containing protein.	0.856
SFB89825.1	SFB89948.1	SAMN04489722_101208	SAMN04489722_101211	RteC protein.	Hypothetical protein.	0.861
SFB89825.1	SFB91168.1	SAMN04489722_101208	SAMN04489722_101242	RteC protein.	Hypothetical protein.	0.767
SFB89825.1	SFB91211.1	SAMN04489722_101208	SAMN04489722_101243	RteC protein.	Hypothetical protein.	0.768
SFB89825.1	SFB91252.1	SAMN04489722_101208	SAMN04489722_101244	RteC protein.	Hypothetical protein.	0.742
SFB89825.1	SFB91291.1	SAMN04489722_101208	SAMN04489722_101245	RteC protein.	Helix-turn-helix domain-containing protein.	0.760
SFB89873.1	SFB89825.1	SAMN04489722_101209	SAMN04489722_101208	Helix-turn-helix domain-containing protein.	RteC protein.	0.856
SFB89873.1	SFB89948.1	SAMN04489722_101209	SAMN04489722_101211	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.951
SFB89873.1	SFB90885.1	SAMN04489722_101209	SAMN04489722_101235	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.507
SFB89873.1	SFB90931.1	SAMN04489722_101209	SAMN04489722_101236	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.407
SFB89873.1	SFB91168.1	SAMN04489722_101209	SAMN04489722_101242	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.777
SFB89873.1	SFB91211.1	SAMN04489722_101209	SAMN04489722_101243	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.774
SFB89873.1	SFB91252.1	SAMN04489722_101209	SAMN04489722_101244	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.783
SFB89873.1	SFB91333.1	SAMN04489722_101209	SAMN04489722_101246	Helix-turn-helix domain-containing protein.	RteC protein.	0.637
SFB89873.1	SFB92970.1	SAMN04489722_101209	SAMN04489722_101289	Helix-turn-helix domain-containing protein.	RteC protein.	0.666
SFB89948.1	SFB89825.1	SAMN04489722_101211	SAMN04489722_101208	Hypothetical protein.	RteC protein.	0.861
SFB89948.1	SFB89873.1	SAMN04489722_101211	SAMN04489722_101209	Hypothetical protein.	Helix-turn-helix domain-containing protein.	0.951
SFB89948.1	SFB90885.1	SAMN04489722_101211	SAMN04489722_101235	Hypothetical protein.	Hypothetical protein.	0.435
SFB89948.1	SFB90931.1	SAMN04489722_101211	SAMN04489722_101236	Hypothetical protein.	Hypothetical protein.	0.568
SFB89948.1	SFB91252.1	SAMN04489722_101211	SAMN04489722_101244	Hypothetical protein.	Hypothetical protein.	0.815

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.886

expected number of edges:

11

PPI enrichment p-value:

3.43e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

7 of 28

1.72

2.98

1.01e-08

GO:0007165

Signal transduction

8 of 43

1.59

2.74

4.89e-09

GO:0006355

Regulation of transcription, DNA-templated

5 of 132

0.9

0.55

0.0214

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

3 of 16

1.6

0.69

0.0413

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032993

protein-DNA complex

5 of 19

1.74

2.3

3.49e-06

GO:0005829

Cytosol

5 of 181

0.76

0.45

0.0335

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3500

ABC-2 family transporter protein, and Two-component regulatory system

5 of 5

2.32

3.51

1.05e-07

CL:2409

Phosphorelay signal transduction system

5 of 15

1.85

2.5

2.11e-06

CL:2411

Protein histidine kinase activity, and OmpR/PhoB-type DNA-binding domain

4 of 10

1.93

2.19

2.28e-05

CL:2310

Cilium, and Signal transduction

6 of 101

1.1

1.05

0.00020

CL:2414

Protein histidine kinase activity

2 of 5

1.93

1.02

0.0109

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 144

1.12

1.43

9.32e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0902

Two-component regulatory system

6 of 11

2.06

3.76

4.69e-09

KW-0597

Phosphoprotein

6 of 17

1.87

3.22

1.89e-08

KW-0805

Transcription regulation

5 of 67

1.2

1.08

0.00060

KW-0238

DNA-binding

5 of 115

0.96

0.71

0.0044

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001867

OmpR/PhoB-type DNA-binding domain

5 of 6

2.24

3.4

1.34e-07

IPR011006

CheY-like superfamily

6 of 12

2.02

3.35

4.12e-08

IPR001789

Signal transduction response regulator, receiver domain

6 of 12

2.02

3.35

4.12e-08

IPR039420

Transcriptional regulatory protein WalR-like

5 of 7

2.18

3.29

1.72e-07

IPR016032

Signal transduction response regulator, C-terminal effector

3 of 8

1.9

1.3

0.0026

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00862

Transcriptional regulatory protein, C terminal

5 of 6

2.24

3.78

1.78e-08

SM00448

cheY-homologous receiver domain

6 of 12

2.02

3.73

3.67e-09

SM00388

His Kinase A (phosphoacceptor) domain

2 of 9

1.67

0.74

0.0349

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