node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAU72685.1 | EAU72788.1 | RS9916_39156 | RS9916_39671 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | COG0067 Glutamate synthase domain 1. | 0.732 |
EAU72685.1 | EAU73275.1 | RS9916_39156 | RS9916_27229 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.866 |
EAU72685.1 | ilvC | RS9916_39156 | RS9916_32817 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.971 |
EAU72685.1 | ilvD | RS9916_39156 | RS9916_29339 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.903 |
EAU72685.1 | leuA | RS9916_39156 | RS9916_31627 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.997 |
EAU72685.1 | leuB | RS9916_39156 | RS9916_29464 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.998 |
EAU72685.1 | leuC | RS9916_39156 | RS9916_39151 | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
EAU72749.1 | EAU72788.1 | RS9916_39476 | RS9916_39671 | Possible aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. | COG0067 Glutamate synthase domain 1. | 0.405 |
EAU72749.1 | ilvD | RS9916_39476 | RS9916_29339 | Possible aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.887 |
EAU72788.1 | EAU72685.1 | RS9916_39671 | RS9916_39156 | COG0067 Glutamate synthase domain 1. | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 0.732 |
EAU72788.1 | EAU72749.1 | RS9916_39671 | RS9916_39476 | COG0067 Glutamate synthase domain 1. | Possible aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. | 0.405 |
EAU72788.1 | EAU73275.1 | RS9916_39671 | RS9916_27229 | COG0067 Glutamate synthase domain 1. | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.788 |
EAU72788.1 | EAU75245.1 | RS9916_39671 | RS9916_37097 | COG0067 Glutamate synthase domain 1. | Aminotransferase class IV; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.533 |
EAU72788.1 | ilvC | RS9916_39671 | RS9916_32817 | COG0067 Glutamate synthase domain 1. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.839 |
EAU72788.1 | ilvD | RS9916_39671 | RS9916_29339 | COG0067 Glutamate synthase domain 1. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.942 |
EAU72788.1 | ilvE | RS9916_39671 | RS9916_30044 | COG0067 Glutamate synthase domain 1. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.533 |
EAU72788.1 | leuA | RS9916_39671 | RS9916_31627 | COG0067 Glutamate synthase domain 1. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.595 |
EAU72788.1 | leuB | RS9916_39671 | RS9916_29464 | COG0067 Glutamate synthase domain 1. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.970 |
EAU72788.1 | leuC | RS9916_39671 | RS9916_39151 | COG0067 Glutamate synthase domain 1. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.814 |
EAU73275.1 | EAU72685.1 | RS9916_27229 | RS9916_39156 | Acetolactate synthase III large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0066 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 0.866 |