STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrDPyrD protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (340 aa)    
Predicted Functional Partners:
pyrE
PyrE protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 0.989
carA
CarA protein; Carbamoylphosphate synthase small subunit; Belongs to the CarA family.
 
  
 0.915
pyrF
PyrF protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.898
pheT
PheT protein; Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.871
carB-2
Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family.
 
 
 0.827
carB
Carbamoylphosphate synthase large subunit (split gene in MJ).
  
 
 0.744
pyrR
PyrR protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
  
  
 0.660
gltD
GltD protein; NADPH-dependent glutamate synthase beta chain and related oxidoreductases.
  
 
 0.646
guaB
GuaB protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.644
guaA
GuaA protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.637
Your Current Organism:
Mannheimia succiniciproducens
NCBI taxonomy Id: 221988
Other names: Mannheimia succiniciproducens MBEL55E, Mannheimia succiniciproducens str. MBEL55E, [. succiniciproducens MBEL55E, [Mannheimia] succiniciproducens MBEL55E
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.