AOS91909.1 protein (Mycobacterium chimaera) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AOS91909.1

Epoxide hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)

Predicted Functional Partners:

AOS94429.1

0.909

AOS91908.1

0.568

AOS90310.1

0.517

AOS90318.1

0.517

AOS90637.1

0.517

AOS90974.1

0.517

APD83947.1

0.517

AOS90987.1

0.517

AOS90988.1

0.517

AOS92009.1

0.517

Your Current Organism:

Mycobacterium chimaera

NCBI taxonomy Id: 222805
Other names: CCUG 50989, CIP 107892, DSM 44623, JCM 14737, M. chimaera, Mycobacterium chimaera Tortoli et al. 2004, NCTC 13781, personal::FI-01069, strain FI-01069

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOS90310.1	AOS90637.1	AN480_00565	AN480_02860	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.766
AOS90310.1	AOS91909.1	AN480_00565	AN480_11325	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Epoxide hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90310.1	AOS94429.1	AN480_00565	AN480_10615	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90318.1	AOS90637.1	AN480_00615	AN480_02860	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.770
AOS90318.1	AOS91909.1	AN480_00615	AN480_11325	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Epoxide hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90318.1	AOS94429.1	AN480_00615	AN480_10615	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90637.1	AOS90310.1	AN480_02860	AN480_00565	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.766
AOS90637.1	AOS90318.1	AN480_02860	AN480_00615	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Mce protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.770
AOS90637.1	AOS91909.1	AN480_02860	AN480_11325	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Epoxide hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90637.1	AOS92009.1	AN480_02860	AN480_12000	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.766
AOS90637.1	AOS94429.1	AN480_02860	AN480_10615	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90637.1	APD83947.1	AN480_02860	AN480_05220	Mammalian cell entry protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
AOS90974.1	AOS91909.1	AN480_05215	AN480_11325	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Epoxide hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90974.1	AOS94429.1	AN480_05215	AN480_10615	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90974.1	APD83947.1	AN480_05215	AN480_05220	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.947
AOS90987.1	AOS90988.1	AN480_05295	AN480_05300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.780
AOS90987.1	AOS91909.1	AN480_05295	AN480_11325	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Epoxide hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90987.1	AOS94429.1	AN480_05295	AN480_10615	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
AOS90987.1	APD83947.1	AN480_05295	AN480_05220	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.772
AOS90988.1	AOS90987.1	AN480_05300	AN480_05295	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.780

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Network Stats

number of nodes:

5

number of edges:

8

average node degree:

3.2

avg. local clustering coefficient:

0.667

expected number of edges:

4

PPI enrichment p-value:

0.0502

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042128

Nitrate assimilation

3 of 17

2.47

1.67

0.00079

GO:0034975

Protein folding in endoplasmic reticulum

2 of 8

2.63

1.04

0.0130

GO:0006790

Sulfur compound metabolic process

4 of 279

1.38

0.84

0.0130

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043546

Molybdopterin cofactor binding

7 of 10

3.07

8.55

9.87e-17

GO:0030151

Molybdenum ion binding

7 of 20

2.77

7.56

2.25e-15

GO:0016670

Oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

6 of 12

2.93

6.87

1.17e-13

GO:0008482

Sulfite oxidase activity

4 of 4

3.23

4.83

1.56e-09

GO:0020037

Heme binding

7 of 162

1.86

3.63

6.79e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

4 of 75

1.96

1.95

9.88e-05

GO:0031967

Organelle envelope

5 of 785

1.03

0.64

0.0172

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21707

Sulfide oxidation to sulfate

4 of 12

2.75

3.45

3.79e-07

CL:21208

Nitrate reductase (NADPH) activity

3 of 5

3.01

2.84

6.80e-06

CL:13456

Mixed, incl. Protein disulfide isomerase activity, and Amino-acid transport

3 of 23

2.34

2.03

0.00014

CL:21719

Sulfide oxidation to sulfate

2 of 6

2.75

1.54

0.0016

CL:21708

Sulfide oxidation to sulfate

2 of 6

2.75

1.54

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

4 of 70

1.99

2.36

1.16e-05

map00910

Nitrogen metabolism

3 of 92

1.74

1.34

0.0016

map04141

Protein processing in endoplasmic reticulum

4 of 334

1.31

1.07

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1614517

Sulfide oxidation to sulfate

4 of 13

2.72

3.64

1.57e-07

MAP-1614558

Degradation of cysteine and homocysteine

4 of 28

2.38

3.06

1.18e-06

MAP-1614635

Sulfur amino acid metabolism

4 of 50

2.13

2.56

6.87e-06

MAP-264876

Insulin processing

2 of 23

2.17

0.88

0.0237

MAP-71291

Metabolism of amino acids and derivatives

4 of 518

1.12

0.6

0.0346

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

5 of 106

1.9

2.71

8.76e-07

KW-0534

Nitrate assimilation

2 of 6

2.75

1.69

0.00084

KW-0500

Molybdenum

2 of 6

2.75

1.69

0.00084

KW-1015

Disulfide bond

2 of 49

1.84

0.85

0.0226

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

7 of 8

3.17

8.84

3.84e-17

PF00174

Oxidoreductase molybdopterin binding domain

7 of 8

3.17

8.84

3.84e-17

PF00970

Oxidoreductase FAD-binding domain

3 of 13

2.59

2.21

7.92e-05

PF00175

Oxidoreductase NAD-binding domain

3 of 26

2.29

1.8

0.00039

PF04137

Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

2 of 2

3.23

1.64

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

7 of 8

3.17

8.62

1.03e-16

IPR008335

Eukaryotic molybdopterin oxidoreductase

7 of 8

3.17

8.62

1.03e-16

IPR000572

Oxidoreductase, molybdopterin-binding domain

7 of 8

3.17

8.62

1.03e-16

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

6 of 7

3.16

7.36

2.56e-14

IPR014756

Immunoglobulin E-set

7 of 39

2.48

6.26

1.71e-13

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 41

2.09

1.53

0.0011

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