AOS93244.1 protein (Mycobacterium chimaera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

AOS93244.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)

Predicted Functional Partners:

AOS93245.1

0.746

AOS93243.1

0.613

AOS93242.1

0.561

AOS93246.1

0.531

Your Current Organism:

Mycobacterium chimaera

NCBI taxonomy Id: 222805
Other names: CCUG 50989, CIP 107892, DSM 44623, JCM 14737, M. chimaera, Mycobacterium chimaera Tortoli et al. 2004, NCTC 13781, personal::FI-01069, strain FI-01069

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOS93242.1	AOS93243.1	AN480_20110	AN480_20115	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
AOS93242.1	AOS93244.1	AN480_20110	AN480_20120	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.561
AOS93242.1	AOS93245.1	AN480_20110	AN480_20125	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.508
AOS93243.1	AOS93242.1	AN480_20115	AN480_20110	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
AOS93243.1	AOS93244.1	AN480_20115	AN480_20120	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.613
AOS93243.1	AOS93245.1	AN480_20115	AN480_20125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.579
AOS93243.1	AOS93246.1	AN480_20115	AN480_20130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
AOS93244.1	AOS93242.1	AN480_20120	AN480_20110	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.561
AOS93244.1	AOS93243.1	AN480_20120	AN480_20115	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.613
AOS93244.1	AOS93245.1	AN480_20120	AN480_20125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
AOS93244.1	AOS93246.1	AN480_20120	AN480_20130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.531
AOS93245.1	AOS93242.1	AN480_20125	AN480_20110	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.508
AOS93245.1	AOS93243.1	AN480_20125	AN480_20115	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.579
AOS93245.1	AOS93244.1	AN480_20125	AN480_20120	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
AOS93245.1	AOS93246.1	AN480_20125	AN480_20130	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.809
AOS93246.1	AOS93243.1	AN480_20130	AN480_20115	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
AOS93246.1	AOS93244.1	AN480_20130	AN480_20120	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.531
AOS93246.1	AOS93245.1	AN480_20130	AN480_20125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.809

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.877

expected number of edges:

11

PPI enrichment p-value:

1.98e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

7 of 9

2.99

8.05

6.82e-16

GO:0006783

Heme biosynthetic process

6 of 13

2.76

6.1

2.23e-12

GO:0006782

Protoporphyrinogen IX biosynthetic process

4 of 7

2.86

4.13

2.24e-08

GO:0070814

Hydrogen sulfide biosynthetic process

3 of 4

2.97

3.02

3.01e-06

GO:0044272

Sulfur compound biosynthetic process

4 of 58

1.94

2.2

2.26e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004783

Sulfite reductase (NADPH) activity

2 of 2

3.1

1.42

0.0027

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

3 of 38

2.0

1.32

0.0027

GO:0016829

Lyase activity

4 of 205

1.39

0.99

0.0048

GO:0003824

Catalytic activity

11 of 3985

0.54

0.43

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009337

Sulfite reductase complex (NADPH)

2 of 2

3.1

1.42

0.0027

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11702

Mixed, incl. Sulfur amino acid metabolic process, and Molybdenum ion binding

11 of 109

2.1

7.26

2.31e-20

CL:11879

Heme biosynthetic process

6 of 11

2.84

6.57

3.42e-13

CL:11881

Heme biosynthetic process

5 of 5

3.1

5.98

9.61e-12

CL:11755

Sulfate assimilation

5 of 5

3.1

5.98

9.61e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

6 of 55

2.14

4.29

3.83e-10

map00920

Sulfur metabolism

5 of 46

2.13

3.64

1.86e-08

map01110

Biosynthesis of secondary metabolites

7 of 669

1.12

1.26

6.63e-06

map01100

Metabolic pathways

11 of 2462

0.75

0.76

2.91e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-189451

Heme biosynthesis

4 of 14

2.55

3.28

6.25e-07

MAP-189445

Metabolism of porphyrins

4 of 15

2.52

3.26

6.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0627

Porphyrin biosynthesis

2 of 4

2.8

1.47

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002891

Adenylyl-sulfate kinase

2 of 2

3.1

1.1

0.0106

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