AOS93641.1 protein (Mycobacterium chimaera) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AOS93641.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)

Predicted Functional Partners:

AOS92272.1

0.794

AOS93422.1

0.794

AOS92728.1

0.793

AOS93527.1

0.793

AOS92407.1

0.792

AOS92991.1

0.792

AOS93706.1

0.791

AOS92465.1

0.790

AOS94519.1

0.779

APD84546.1

0.778

Your Current Organism:

Mycobacterium chimaera

NCBI taxonomy Id: 222805
Other names: CCUG 50989, CIP 107892, DSM 44623, JCM 14737, M. chimaera, Mycobacterium chimaera Tortoli et al. 2004, NCTC 13781, personal::FI-01069, strain FI-01069

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOS92272.1	AOS93641.1	AN480_13850	AN480_22670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.794
AOS92272.1	AOS94519.1	AN480_13850	AN480_15355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.726
AOS92272.1	APD84546.1	AN480_13850	AN480_24200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.725
AOS92407.1	AOS93641.1	AN480_14700	AN480_22670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.792
AOS92407.1	AOS94519.1	AN480_14700	AN480_15355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.715
AOS92407.1	APD84546.1	AN480_14700	AN480_24200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.711
AOS92465.1	AOS93641.1	AN480_15060	AN480_22670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.790
AOS92465.1	AOS94519.1	AN480_15060	AN480_15355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.709
AOS92465.1	APD84546.1	AN480_15060	AN480_24200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.704
AOS92728.1	AOS93641.1	AN480_16800	AN480_22670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.793
AOS92728.1	AOS94519.1	AN480_16800	AN480_15355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720
AOS92728.1	APD84546.1	AN480_16800	AN480_24200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.718
AOS92991.1	AOS93641.1	AN480_18485	AN480_22670	Maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.792
AOS92991.1	AOS94519.1	AN480_18485	AN480_15355	Maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.668
AOS93422.1	AOS93641.1	AN480_21260	AN480_22670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.794
AOS93422.1	AOS94519.1	AN480_21260	AN480_15355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.725
AOS93422.1	APD84546.1	AN480_21260	AN480_24200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.723
AOS93527.1	AOS93641.1	AN480_21955	AN480_22670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.793
AOS93527.1	AOS94519.1	AN480_21955	AN480_15355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.712
AOS93527.1	APD84546.1	AN480_21955	AN480_24200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.709

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

13

PPI enrichment p-value:

0.162

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006707

Cholesterol catabolic process

3 of 11

2.4

1.75

0.00053

GO:0006629

Lipid metabolic process

6 of 437

1.11

0.99

0.00055

GO:0006633

Fatty acid biosynthetic process

3 of 103

1.43

0.77

0.0220

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 29

1.98

1.22

0.0044

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

3 of 35

1.9

1.2

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9435

Mixed, incl. GMC oxidoreductase, and Oxygen oxidoreductase covalent FAD-binding site

3 of 6

2.67

2.04

0.00018

CL:2969

Mixed, incl. DUF35 OB-fold domain, acyl-CoA-associated, and Thiolase

3 of 10

2.44

1.89

0.00030

CL:3441

ACP-like superfamily, and MbtH-like domain

3 of 55

1.7

1.09

0.0057

CL:3450

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group., and Male sterility protein

2 of 11

2.23

1.07

0.0103

CL:3430

Mixed, incl. ACP-like superfamily, and Cytochrome P450

4 of 163

1.36

0.96

0.0053

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

kphy00984

Steroid degradation

3 of 17

2.21

2.0

0.00014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034081

Polyketide synthase complex

3 of 28

2.0

1.46

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0001

2Fe-2S

2 of 9

2.31

1.14

0.0076

KW-0596

Phosphopantetheine

3 of 59

1.67

1.03

0.0076

KW-0408

Iron

3 of 160

1.24

0.6

0.0449

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00975

Thioesterase domain

3 of 9

2.49

1.98

0.00021

PF05199

GMC oxidoreductase

2 of 9

2.31

0.83

0.0295

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 11

2.23

0.83

0.0295

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001031

Thioesterase

3 of 12

2.37

1.61

0.0010

IPR006162

Phosphopantetheine attachment site

3 of 29

1.98

1.17

0.0056

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

3 of 35

1.9

1.12

0.0064

IPR007867

Glucose-methanol-choline oxidoreductase, C-terminal

2 of 9

2.31

0.88

0.0239

IPR000172

Glucose-methanol-choline oxidoreductase, N-terminal

2 of 9

2.31

0.88

0.0239

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

3 of 20

2.14

1.81

0.00031

SM00826

PKS_DH

2 of 11

2.23

1.13

0.0078

SM00825

Beta-ketoacyl synthase

2 of 12

2.19

1.13

0.0078

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 14

2.12

1.12

0.0078

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

2 of 15

2.09

1.11

0.0078

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