node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AS25_00270 | panB | AS25_00270 | AS25_05035 | NADH-ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.861 |
AS25_00270 | panC | AS25_00270 | AS25_00265 | NADH-ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.991 |
AS25_00270 | panD | AS25_00270 | AS25_07855 | NADH-ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate 1-decarboxylase subunit alpha; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.441 |
AS25_05095 | panB | AS25_05095 | AS25_05035 | Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.657 |
AS25_05095 | panC | AS25_05095 | AS25_00265 | Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.526 |
AS25_05095 | panD | AS25_05095 | AS25_07855 | Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. | Aspartate 1-decarboxylase subunit alpha; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.508 |
AS25_07925 | ilvD | AS25_07925 | AS25_01900 | Aminodeoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | 0.939 |
AS25_07925 | panB | AS25_07925 | AS25_05035 | Aminodeoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.757 |
AS25_09370 | ilvD | AS25_09370 | AS25_01900 | Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | 0.996 |
AS25_09370 | panB | AS25_09370 | AS25_05035 | Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.927 |
ftsH | guaA | AS25_00310 | AS25_13450 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.411 |
ftsH | pafA | AS25_00310 | AS25_03510 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.439 |
ftsH | panB | AS25_00310 | AS25_05035 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.606 |
guaA | ftsH | AS25_13450 | AS25_00310 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.411 |
guaA | ilvD | AS25_13450 | AS25_01900 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | 0.505 |
guaA | panB | AS25_13450 | AS25_05035 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.624 |
guaA | panC | AS25_13450 | AS25_00265 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.513 |
ilvD | AS25_07925 | AS25_01900 | AS25_07925 | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | Aminodeoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.939 |
ilvD | AS25_09370 | AS25_01900 | AS25_09370 | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.996 |
ilvD | guaA | AS25_01900 | AS25_13450 | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.505 |