node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO55791.1 | AAO56532.1 | PSPTO_2277 | PSPTO_3043 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 0.910 |
AAO55791.1 | AAO58825.1 | PSPTO_2277 | PSPTO_5403 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | 0.900 |
AAO55791.1 | dut | PSPTO_2277 | PSPTO_0084 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
AAO55791.1 | surE | PSPTO_2277 | PSPTO_1562 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AAO55791.1 | thyA | PSPTO_2277 | PSPTO_5282 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
AAO55791.1 | tmk | PSPTO_2277 | PSPTO_3827 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
AAO56532.1 | AAO55791.1 | PSPTO_3043 | PSPTO_2277 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 0.910 |
AAO56532.1 | AAO58825.1 | PSPTO_3043 | PSPTO_5403 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | 0.900 |
AAO56532.1 | dut | PSPTO_3043 | PSPTO_0084 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
AAO56532.1 | surE | PSPTO_3043 | PSPTO_1562 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AAO56532.1 | thyA | PSPTO_3043 | PSPTO_5282 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
AAO56532.1 | tmk | PSPTO_3043 | PSPTO_3827 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
AAO58825.1 | AAO55791.1 | PSPTO_5403 | PSPTO_2277 | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 0.900 |
AAO58825.1 | AAO56532.1 | PSPTO_5403 | PSPTO_3043 | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 0.900 |
AAO58825.1 | dut | PSPTO_5403 | PSPTO_0084 | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.901 |
AAO58825.1 | surE | PSPTO_5403 | PSPTO_1562 | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.911 |
AAO58825.1 | thyA | PSPTO_5403 | PSPTO_5282 | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.902 |
AAO58825.1 | tmk | PSPTO_5403 | PSPTO_3827 | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.901 |
coaBC | dut | PSPTO_0085 | PSPTO_0084 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.963 |
dcd | dut | PSPTO_4144 | PSPTO_0084 | Deoxycytidine triphosphate deaminase, putative; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.929 |