Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AAO55654.1MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. (75 aa)    
Predicted Functional Partners:
AAO57967.1
This gene is aparrently the terminal component of a non-ribosomal peptide synthetase (due to the presence of the terminal thioesterase domain) and is most likely associated with the previous gene which appears to be a initiating component. This gene contains three complete amino acid activation, thiolation and condensation domain modules and appears to be specific for glycine, an unidentified amino acid and serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a previously undesc [...]
 
 
 0.999
cmaA
Coronamic acid synthetase CmaA; Non-ribosomal peptide synthetase with adenylation and thiolation domains; reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis; see PMID: 14679222; see PMID:20190049 for expression data; non-ribosomal peptide synthetase with adenylation and thiolation domains, reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis, see PMID: 14679222.
 
 
 0.999
AAO57966.1
This gene is aparrently the initiating component of a non-ribosomal peptide synthetase (due to the presence of an initial non-amino acid adenylation/ligase domain) and is most likely associated with the following gene which appears to be a terminating component. This gene contains a thiolation domain as well as one complete amino acid activation, thiolation and condensation domain modules which appears to be specific for serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a pre [...]
 
 
 0.995
AAO55666.1
Pyoverdine sidechain peptide synthetase III, L-Thr-L-Ser component; This synthetase is the fourth module (of five) in the biosynthesis of the P. syringae pyoverdine peptide which is subsequently modified by various enzymes to produce the mature pyoverdine siderophore; see PMID:20190049 for expression data; similar to GP:13094061; identified by sequence similarity; putative.
 
 
 0.993
syfA
Non-ribosomal peptide synthetase SyfA; This gene consists of three complete condensation, adenylation, thiolation domain modules. The adenylation domains are specific for leucine, leucine and glutamine; together with PSPTO_2830 codes for proteins involved in production of lipopeptide syringofactins. See PMID:17601782.
 
 
 0.993
syfB
Non-ribosomal peptide synthetase SyfB; This gene consists of five complete condensation, adenylation, thiolation domain modules followed by two thioesterase domains. The adenylation domains are specific for leucine, threonine, valine, leucine and leucine; together with PSPTO_2829 codes for proteins involved in production of lipopeptide syringofactins. See PMID:17601782.
 
 
 0.993
AAO58141.1
Non-ribosomal peptide synthetase, terminal component; This gene consists of four complete condensation-amino acid adenylation/ligation-thiolation modules followed by a thioesterase. The initial condensation domain implies that another thiolation domain-containing protein precedes this one in the functional complex although no such component is found upstream of this gene. This gene is found within the coronatine biosynthesis gene cluster and does not appear to be functionally related to those genes. Prediction of amino acid specificities at http://raynam.chm.jhu.edu/; nrps/index2.html [...]
 
 
 0.993
pvsA
Pyoverdine chromophore precursor synthetase; This synthetase is the first component (of five) in the biosynthesis of the P. syringae pyoverdine peptide which is subsequently modified by various enzymes to produce the mature pyoverdine siderophore. This module initiates the chain and synthesizes the tripeptide L-glutamate:D-tyrosine:L-2-diaminobutyrate which is the constant feature of all pyoverdines and is subsequently converted to the fluorescent chromophore; see PMID:20190049 for expression data; similar to GP:440169; identified by sequence similarity; putative.
 
 
 0.986
mgoA
Ornithine acetyl transferase inhibitor; This enzyme consists of an amino acid activation and ligation domain followed by a thiolation domaintypical of non-ribosomal peptide synthetases; similar to the ornithine acetyl transferase inhibitor mangotoxin; see PMID:17506328.
 
 
 0.984
cfa6
Coronafacic acid polyketide synthase I; This gene is the first of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPC (2-carboxy-2-cyclopentenone) from an acyl carrier protein (cfa1), it then adds a buyrate group and then completely reduces the ketone of the (former) carboxylate group. The resulting product is then passed to the second polyketide synthetase (cfa7); similar to GP:13346874; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the first of two multi [...]
 
 
 0.912
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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