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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (213 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
 
 0.998
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.987
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.954
hom
Homoserine dehydrogenase; See PMID:20190049 for expression data.
  
  
 0.925
poxB
Pyruvate dehydrogenase; Similar to SP:P07003, GB:J03600, GB:J03571, SP:P09917, PID:187167, PID:187169, PID:187193, and PID:388525; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
 
 
 0.914
ilvD
Dihydroxy-acid dehydratase; Similar to SP:P05791; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to SP:P05791, identified by sequence similarity, putative; Belongs to the IlvD/Edd family.
 
  
 0.909
ilvN
Acetolactate synthase, small subunit; Similar to SP:P00894; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to SP:P00894, identified by sequence similarity, putative.
 
  
 0.873
AAO56688.1
Dehydrogenase, isocitrate/isopropylmalate family; Similar to SP:P37149, GB:U12289, PID:516036, PID:882720, GB:U00096, and PID:1789192; identified by sequence similarity; putative.
 
  
 0.866
AAO56164.1
Tartrate dehydrogenase; Similar to SP:Q51945, and SP:Q51945; identified by sequence similarity; putative.
 
  
 0.857
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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