| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAO55651.1 | AAO55654.1 | PSPTO_2134 | PSPTO_2137 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | 0.882 |
| AAO55651.1 | AAO56106.1 | PSPTO_2134 | PSPTO_2602 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | Yersiniabactin non-ribosomal peptide synthetase; Catalyzes the condensation of salicylate with two molecules of cysteine which are both cyclized to thiazoline rings. This enzyme contains a single adenylation domain which most likely charges both of final two thiolation domains with cysteine. Following the adenylation domain is an unidentified domain which most likely provides the docking site for the thiazoline reductase (irp3) which reduces the second thiazoline ring. The product of this synthetase may be released in trans by the thioesterase component (irp4) or directly transferred t [...] | 0.849 |
| AAO55651.1 | AAO57967.1 | PSPTO_2134 | PSPTO_4519 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | This gene is aparrently the terminal component of a non-ribosomal peptide synthetase (due to the presence of the terminal thioesterase domain) and is most likely associated with the previous gene which appears to be a initiating component. This gene contains three complete amino acid activation, thiolation and condensation domain modules and appears to be specific for glycine, an unidentified amino acid and serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a previously undesc [...] | 0.998 |
| AAO55651.1 | cfa6 | PSPTO_2134 | PSPTO_4686 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | Coronafacic acid polyketide synthase I; This gene is the first of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPC (2-carboxy-2-cyclopentenone) from an acyl carrier protein (cfa1), it then adds a buyrate group and then completely reduces the ketone of the (former) carboxylate group. The resulting product is then passed to the second polyketide synthetase (cfa7); similar to GP:13346874; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the first of two multi [...] | 0.939 |
| AAO55651.1 | cfa7 | PSPTO_2134 | PSPTO_4687 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | Coronafacic acid polyketide synthetase II; This gene is the second of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPE (2-[1-oxo-2-cyclopenten-2-ylmethyl]butanoic acid) from the first synthetase, Cpe6. It then adds one final acetate group, catalyzes the cyclization of the second ring and converts a ketone to a double bond. The product is released by a terminal thioesterase domain; similar to GP:13162634; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the [...] | 0.840 |
| AAO55651.1 | cmaA | PSPTO_2134 | PSPTO_4709 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | Coronamic acid synthetase CmaA; Non-ribosomal peptide synthetase with adenylation and thiolation domains; reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis; see PMID: 14679222; see PMID:20190049 for expression data; non-ribosomal peptide synthetase with adenylation and thiolation domains, reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis, see PMID: 14679222. | 0.998 |
| AAO55651.1 | irp1 | PSPTO_2134 | PSPTO_2600 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | This synthetase catalyzes the final steps in the biosynthesis of the siderophore yersiniabactin, adding one acetate unit with concomitant reduction to the alcohol and dimethylation followed by the addition, cyclization and methylation of one cysteine residue. The final product is released by the terminal thioesterase domain; similar to GP:4106636; identified by sequence similarity; putative; see PMID:20190049 for expression data; This synthetase catalyzes the final steps in the biosynthesis of the siderophore yersiniabactin, adding one acetate unit with concomitant reduction to the alc [...] | 0.842 |
| AAO55651.1 | irp3 | PSPTO_2134 | PSPTO_2599 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | Yersiniabactin synthetase, thiazolinyl reductase component; This enzyme reduces the carbon-nitrogen bond of the second of three thiazoline rings of the siderophore yersiniabactin. Most probably this reduction takes place while an intermediate of the biosynthesis is still bound to irp2, the non-ribosomal peptide synthetase component, due to the presence of a conserved domain likely to function as a docking site for the reductase; similar to GP:2765196; identified by sequence similarity; putative; see PMID:20190049 for expression data; This enzyme reduces the carbon-nitrogen bond of the [...] | 0.768 |
| AAO55651.1 | irp5 | PSPTO_2134 | PSPTO_2597 | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | Yersiniabactin synthetase, salycilate ligase component; Activates salicylate by adenylation and transfers the salicylyl moiety to irp2, the non-ribosomal peptide synthetase component of yersiniabactin synthetase. Yersiniabactin is a siderophore; see PMID:20190049 for expression data; similar to SP:P40871, GP:2765198, GB:X68560, SP:Q02447, PID:338303, and PID:38418; identified by sequence similarity; putative. | 0.683 |
| AAO55654.1 | AAO55651.1 | PSPTO_2137 | PSPTO_2134 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | 0.882 |
| AAO55654.1 | AAO56106.1 | PSPTO_2137 | PSPTO_2602 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Yersiniabactin non-ribosomal peptide synthetase; Catalyzes the condensation of salicylate with two molecules of cysteine which are both cyclized to thiazoline rings. This enzyme contains a single adenylation domain which most likely charges both of final two thiolation domains with cysteine. Following the adenylation domain is an unidentified domain which most likely provides the docking site for the thiazoline reductase (irp3) which reduces the second thiazoline ring. The product of this synthetase may be released in trans by the thioesterase component (irp4) or directly transferred t [...] | 0.815 |
| AAO55654.1 | AAO57967.1 | PSPTO_2137 | PSPTO_4519 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | This gene is aparrently the terminal component of a non-ribosomal peptide synthetase (due to the presence of the terminal thioesterase domain) and is most likely associated with the previous gene which appears to be a initiating component. This gene contains three complete amino acid activation, thiolation and condensation domain modules and appears to be specific for glycine, an unidentified amino acid and serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a previously undesc [...] | 0.999 |
| AAO55654.1 | cfa6 | PSPTO_2137 | PSPTO_4686 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Coronafacic acid polyketide synthase I; This gene is the first of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPC (2-carboxy-2-cyclopentenone) from an acyl carrier protein (cfa1), it then adds a buyrate group and then completely reduces the ketone of the (former) carboxylate group. The resulting product is then passed to the second polyketide synthetase (cfa7); similar to GP:13346874; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the first of two multi [...] | 0.912 |
| AAO55654.1 | cfa7 | PSPTO_2137 | PSPTO_4687 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Coronafacic acid polyketide synthetase II; This gene is the second of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPE (2-[1-oxo-2-cyclopenten-2-ylmethyl]butanoic acid) from the first synthetase, Cpe6. It then adds one final acetate group, catalyzes the cyclization of the second ring and converts a ketone to a double bond. The product is released by a terminal thioesterase domain; similar to GP:13162634; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the [...] | 0.911 |
| AAO55654.1 | cmaA | PSPTO_2137 | PSPTO_4709 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Coronamic acid synthetase CmaA; Non-ribosomal peptide synthetase with adenylation and thiolation domains; reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis; see PMID: 14679222; see PMID:20190049 for expression data; non-ribosomal peptide synthetase with adenylation and thiolation domains, reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis, see PMID: 14679222. | 0.999 |
| AAO55654.1 | irp1 | PSPTO_2137 | PSPTO_2600 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | This synthetase catalyzes the final steps in the biosynthesis of the siderophore yersiniabactin, adding one acetate unit with concomitant reduction to the alcohol and dimethylation followed by the addition, cyclization and methylation of one cysteine residue. The final product is released by the terminal thioesterase domain; similar to GP:4106636; identified by sequence similarity; putative; see PMID:20190049 for expression data; This synthetase catalyzes the final steps in the biosynthesis of the siderophore yersiniabactin, adding one acetate unit with concomitant reduction to the alc [...] | 0.697 |
| AAO55654.1 | irp4 | PSPTO_2137 | PSPTO_2598 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Yersiniabactin synthetase, thioesterase component; Possibly involved in the release of an intermediate product see PMID:20190049 for expression data; similar to pyochelin, since the terminal yersiniabactin synthetase has its own thioesterase domain; see PMID:20190049 for expression data; similar to GP:3818607; identified by sequence similarity; putative. | 0.830 |
| AAO55654.1 | irp5 | PSPTO_2137 | PSPTO_2597 | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | Yersiniabactin synthetase, salycilate ligase component; Activates salicylate by adenylation and transfers the salicylyl moiety to irp2, the non-ribosomal peptide synthetase component of yersiniabactin synthetase. Yersiniabactin is a siderophore; see PMID:20190049 for expression data; similar to SP:P40871, GP:2765198, GB:X68560, SP:Q02447, PID:338303, and PID:38418; identified by sequence similarity; putative. | 0.681 |
| AAO56106.1 | AAO55651.1 | PSPTO_2602 | PSPTO_2134 | Yersiniabactin non-ribosomal peptide synthetase; Catalyzes the condensation of salicylate with two molecules of cysteine which are both cyclized to thiazoline rings. This enzyme contains a single adenylation domain which most likely charges both of final two thiolation domains with cysteine. Following the adenylation domain is an unidentified domain which most likely provides the docking site for the thiazoline reductase (irp3) which reduces the second thiazoline ring. The product of this synthetase may be released in trans by the thioesterase component (irp4) or directly transferred t [...] | Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative. | 0.849 |
| AAO56106.1 | AAO55654.1 | PSPTO_2602 | PSPTO_2137 | Yersiniabactin non-ribosomal peptide synthetase; Catalyzes the condensation of salicylate with two molecules of cysteine which are both cyclized to thiazoline rings. This enzyme contains a single adenylation domain which most likely charges both of final two thiolation domains with cysteine. Following the adenylation domain is an unidentified domain which most likely provides the docking site for the thiazoline reductase (irp3) which reduces the second thiazoline ring. The product of this synthetase may be released in trans by the thioesterase component (irp4) or directly transferred t [...] | MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative. | 0.815 |
