Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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syfANon-ribosomal peptide synthetase SyfA; This gene consists of three complete condensation, adenylation, thiolation domain modules. The adenylation domains are specific for leucine, leucine and glutamine; together with PSPTO_2830 codes for proteins involved in production of lipopeptide syringofactins. See PMID:17601782. (3168 aa)    
Predicted Functional Partners:
AAO57967.1
This gene is aparrently the terminal component of a non-ribosomal peptide synthetase (due to the presence of the terminal thioesterase domain) and is most likely associated with the previous gene which appears to be a initiating component. This gene contains three complete amino acid activation, thiolation and condensation domain modules and appears to be specific for glycine, an unidentified amino acid and serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a previously undesc [...]
 
 
0.999
cmaA
Coronamic acid synthetase CmaA; Non-ribosomal peptide synthetase with adenylation and thiolation domains; reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis; see PMID: 14679222; see PMID:20190049 for expression data; non-ribosomal peptide synthetase with adenylation and thiolation domains, reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis, see PMID: 14679222.
 
 
0.999
cfa6
Coronafacic acid polyketide synthase I; This gene is the first of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPC (2-carboxy-2-cyclopentenone) from an acyl carrier protein (cfa1), it then adds a buyrate group and then completely reduces the ketone of the (former) carboxylate group. The resulting product is then passed to the second polyketide synthetase (cfa7); similar to GP:13346874; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the first of two multi [...]
 
 
 0.996
cfa7
Coronafacic acid polyketide synthetase II; This gene is the second of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPE (2-[1-oxo-2-cyclopenten-2-ylmethyl]butanoic acid) from the first synthetase, Cpe6. It then adds one final acetate group, catalyzes the cyclization of the second ring and converts a ketone to a double bond. The product is released by a terminal thioesterase domain; similar to GP:13162634; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the [...]
  
 0.995
AAO55654.1
MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative.
 
 
 0.993
AAO57969.1
Conserved protein of unknown function; See PMID:20190049 for expression data; similar to GP:9937237, and GP:17431110; identified by sequence similarity; putative.
 
 
 0.993
mgoA
Ornithine acetyl transferase inhibitor; This enzyme consists of an amino acid activation and ligation domain followed by a thiolation domaintypical of non-ribosomal peptide synthetases; similar to the ornithine acetyl transferase inhibitor mangotoxin; see PMID:17506328.
 
  
0.981
pvdE
Pyoverdine ABC transporter, ATP-binding/permease protein; See PMID:20190049 for expression data; similar to GP:466460, GB:X06325, SP:P09002, and PID:1333690; identified by sequence similarity; putative.
 
  
 0.908
AAO55651.1
Pyoverdine synthetase, thioesterase component; Presumed to be involved in the biosynthesis of pyoverdine due to proximity to the rest of the pyoverdine biosynthetic gene cluster. Possibly acts to release the pyoverdine chromophore precursor from PvsA; see PMID:20190049 for expression data; similar to GP:9948471; identified by sequence similarity; putative.
 
  
 0.891
irp4
Yersiniabactin synthetase, thioesterase component; Possibly involved in the release of an intermediate product see PMID:20190049 for expression data; similar to pyochelin, since the terminal yersiniabactin synthetase has its own thioesterase domain; see PMID:20190049 for expression data; similar to GP:3818607; identified by sequence similarity; putative.
 
  
 0.888
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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