node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO55936.1 | fmt | PSPTO_2427 | PSPTO_0178 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
AAO55936.1 | folD-2 | PSPTO_2427 | PSPTO_3733 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
AAO55936.1 | gcvT-1 | PSPTO_2427 | PSPTO_0316 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.960 |
AAO55936.1 | gcvT-2 | PSPTO_2427 | PSPTO_1275 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Glycine cleavage system T protein; See PMID:20190049 for expression data. | 0.959 |
AAO55936.1 | glyA-1 | PSPTO_2427 | PSPTO_0461 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
AAO55936.1 | glyA-2 | PSPTO_2427 | PSPTO_4632 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
AAO55936.1 | purH | PSPTO_2427 | PSPTO_4866 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; See PMID:20190049 for expression data. | 0.966 |
AAO55936.1 | purN | PSPTO_2427 | PSPTO_1699 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.947 |
AAO55936.1 | thyA | PSPTO_2427 | PSPTO_5282 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.917 |
AAO58653.1 | fmt | PSPTO_5227 | PSPTO_0178 | Identified by match to PFAM protein family HMM PF01812; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.462 |
AAO58653.1 | folD-2 | PSPTO_5227 | PSPTO_3733 | Identified by match to PFAM protein family HMM PF01812; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
AAO58653.1 | purN | PSPTO_5227 | PSPTO_1699 | Identified by match to PFAM protein family HMM PF01812; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.944 |
fmt | AAO55936.1 | PSPTO_0178 | PSPTO_2427 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | 0.910 |
fmt | AAO58653.1 | PSPTO_0178 | PSPTO_5227 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Identified by match to PFAM protein family HMM PF01812; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.462 |
fmt | folD-2 | PSPTO_0178 | PSPTO_3733 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.960 |
fmt | gcvT-1 | PSPTO_0178 | PSPTO_0316 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
fmt | gcvT-2 | PSPTO_0178 | PSPTO_1275 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; See PMID:20190049 for expression data. | 0.914 |
fmt | glyA-1 | PSPTO_0178 | PSPTO_0461 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
fmt | glyA-2 | PSPTO_0178 | PSPTO_4632 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
fmt | purN | PSPTO_0178 | PSPTO_1699 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.940 |