node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO54098.1 | murA | PSPTO_0556 | PSPTO_4441 | Nucleotidyltransferase family protein; See PMID:20190049 for expression data. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.811 |
AAO54098.1 | murB | PSPTO_0556 | PSPTO_3842 | Nucleotidyltransferase family protein; See PMID:20190049 for expression data. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.902 |
AAO54098.1 | murC | PSPTO_0556 | PSPTO_4407 | Nucleotidyltransferase family protein; See PMID:20190049 for expression data. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.806 |
AAO57311.1 | kdsB | PSPTO_3844 | PSPTO_3843 | Conserved protein of unknown function; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF03966; Belongs to the UPF0434 family. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.854 |
AAO57311.1 | lpxK | PSPTO_3844 | PSPTO_3845 | Conserved protein of unknown function; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF03966; Belongs to the UPF0434 family. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.787 |
AAO57311.1 | murB | PSPTO_3844 | PSPTO_3842 | Conserved protein of unknown function; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF03966; Belongs to the UPF0434 family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.699 |
birA | murB | PSPTO_0610 | PSPTO_3842 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.781 |
era | murB | PSPTO_4216 | PSPTO_3842 | GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.695 |
kdsB | AAO57311.1 | PSPTO_3843 | PSPTO_3844 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Conserved protein of unknown function; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF03966; Belongs to the UPF0434 family. | 0.854 |
kdsB | lpxK | PSPTO_3843 | PSPTO_3845 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.963 |
kdsB | murB | PSPTO_3843 | PSPTO_3842 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.765 |
lpxK | AAO57311.1 | PSPTO_3845 | PSPTO_3844 | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | Conserved protein of unknown function; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF03966; Belongs to the UPF0434 family. | 0.787 |
lpxK | kdsB | PSPTO_3845 | PSPTO_3843 | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.963 |
lpxK | murA | PSPTO_3845 | PSPTO_4441 | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.416 |
lpxK | murB | PSPTO_3845 | PSPTO_3842 | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.703 |
murA | AAO54098.1 | PSPTO_4441 | PSPTO_0556 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | Nucleotidyltransferase family protein; See PMID:20190049 for expression data. | 0.811 |
murA | lpxK | PSPTO_4441 | PSPTO_3845 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.416 |
murA | murB | PSPTO_4441 | PSPTO_3842 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.943 |
murA | murC | PSPTO_4441 | PSPTO_4407 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.847 |
murA | murE | PSPTO_4441 | PSPTO_4413 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.826 |