STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hopAD1Type III effector HopAD1; Previously known as HolPtoS (PMID11872842; Guttman et al, 2002) and HopPtoI (PMID12032338; Petnicki-Ocwieja et al, 2002); see PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF02918. (632 aa)    
Predicted Functional Partners:
AAO57967.1
This gene is aparrently the terminal component of a non-ribosomal peptide synthetase (due to the presence of the terminal thioesterase domain) and is most likely associated with the previous gene which appears to be a initiating component. This gene contains three complete amino acid activation, thiolation and condensation domain modules and appears to be specific for glycine, an unidentified amino acid and serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a previously undesc [...]
  
 
 0.932
cmaA
Coronamic acid synthetase CmaA; Non-ribosomal peptide synthetase with adenylation and thiolation domains; reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis; see PMID: 14679222; see PMID:20190049 for expression data; non-ribosomal peptide synthetase with adenylation and thiolation domains, reacts with the AMP derivative of L-allo-isoleucine to produce an aminoacyl thiolester intermediate during coronamic acid biosynthesis, see PMID: 14679222.
  
 
 0.932
AAO57966.1
This gene is aparrently the initiating component of a non-ribosomal peptide synthetase (due to the presence of an initial non-amino acid adenylation/ligase domain) and is most likely associated with the following gene which appears to be a terminating component. This gene contains a thiolation domain as well as one complete amino acid activation, thiolation and condensation domain modules which appears to be specific for serine according to the prediction algorithm at http://raynam.chm.jhu.edu/; nrps/index2.html. Taken together these two genes appear to direct the biosynthesis of a pre [...]
  
 
 0.664
cfa6
Coronafacic acid polyketide synthase I; This gene is the first of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPC (2-carboxy-2-cyclopentenone) from an acyl carrier protein (cfa1), it then adds a buyrate group and then completely reduces the ketone of the (former) carboxylate group. The resulting product is then passed to the second polyketide synthetase (cfa7); similar to GP:13346874; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the first of two multi [...]
  
 
 0.638
mgoA
Ornithine acetyl transferase inhibitor; This enzyme consists of an amino acid activation and ligation domain followed by a thiolation domaintypical of non-ribosomal peptide synthetases; similar to the ornithine acetyl transferase inhibitor mangotoxin; see PMID:17506328.
  
 
 0.539
AAO55654.1
MbtH-like protein; See PMID:20190049 for expression data; similar to GP:15159638; identified by sequence similarity; putative.
  
  
 0.521
AAO57969.1
Conserved protein of unknown function; See PMID:20190049 for expression data; similar to GP:9937237, and GP:17431110; identified by sequence similarity; putative.
  
  
 0.521
pvdE
Pyoverdine ABC transporter, ATP-binding/permease protein; See PMID:20190049 for expression data; similar to GP:466460, GB:X06325, SP:P09002, and PID:1333690; identified by sequence similarity; putative.
  
  
 0.509
cfa7
Coronafacic acid polyketide synthetase II; This gene is the second of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPE (2-[1-oxo-2-cyclopenten-2-ylmethyl]butanoic acid) from the first synthetase, Cpe6. It then adds one final acetate group, catalyzes the cyclization of the second ring and converts a ketone to a double bond. The product is released by a terminal thioesterase domain; similar to GP:13162634; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the [...]
  
  
 0.491
AAO55666.1
Pyoverdine sidechain peptide synthetase III, L-Thr-L-Ser component; This synthetase is the fourth module (of five) in the biosynthesis of the P. syringae pyoverdine peptide which is subsequently modified by various enzymes to produce the mature pyoverdine siderophore; see PMID:20190049 for expression data; similar to GP:13094061; identified by sequence similarity; putative.
  
 
 0.449
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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