node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobC | hisA | PSPTO_1712 | PSPTO_5335 | Cobalamin biosynthesis protein CobC. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | 0.764 |
cobC | hisB | PSPTO_1712 | PSPTO_5338 | Cobalamin biosynthesis protein CobC. | Imidazoleglycerol-phosphate dehydratase; See PMID:20190049 for expression data; similar to SP:O34683, GB:L29436, and PID:459909; identified by sequence similarity; putative. | 0.798 |
cobC | hisD | PSPTO_1712 | PSPTO_4438 | Cobalamin biosynthesis protein CobC. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.793 |
cobC | hisE | PSPTO_1712 | PSPTO_5154 | Cobalamin biosynthesis protein CobC. | phosphoribosyl-ATP pyrophosphatase; See PMID:20190049 for expression data. | 0.748 |
cobC | hisF | PSPTO_1712 | PSPTO_5334 | Cobalamin biosynthesis protein CobC. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.764 |
cobC | hisG | PSPTO_1712 | PSPTO_4439 | Cobalamin biosynthesis protein CobC. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.764 |
cobC | hisH | PSPTO_1712 | PSPTO_5337 | Cobalamin biosynthesis protein CobC. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.764 |
cobC | hisI | PSPTO_1712 | PSPTO_5153 | Cobalamin biosynthesis protein CobC. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.792 |
cobC | hisZ | PSPTO_1712 | PSPTO_4938 | Cobalamin biosynthesis protein CobC. | ATP phosphoribosyltransferase regulatory subunit, putative; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.675 |
hisA | cobC | PSPTO_5335 | PSPTO_1712 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | Cobalamin biosynthesis protein CobC. | 0.764 |
hisA | hisB | PSPTO_5335 | PSPTO_5338 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | Imidazoleglycerol-phosphate dehydratase; See PMID:20190049 for expression data; similar to SP:O34683, GB:L29436, and PID:459909; identified by sequence similarity; putative. | 0.996 |
hisA | hisC | PSPTO_5335 | PSPTO_4437 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | Histidinol-phosphate aminotransferase; Identified by match to TIGR protein family HMM TIGR01265; see PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01265; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.891 |
hisA | hisD | PSPTO_5335 | PSPTO_4438 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.985 |
hisA | hisE | PSPTO_5335 | PSPTO_5154 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | phosphoribosyl-ATP pyrophosphatase; See PMID:20190049 for expression data. | 0.982 |
hisA | hisF | PSPTO_5335 | PSPTO_5334 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | PSPTO_5335 | PSPTO_4439 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.983 |
hisA | hisH | PSPTO_5335 | PSPTO_5337 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | PSPTO_5335 | PSPTO_5153 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | PSPTO_5335 | PSPTO_4938 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR00735. | ATP phosphoribosyltransferase regulatory subunit, putative; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.919 |
hisB | cobC | PSPTO_5338 | PSPTO_1712 | Imidazoleglycerol-phosphate dehydratase; See PMID:20190049 for expression data; similar to SP:O34683, GB:L29436, and PID:459909; identified by sequence similarity; putative. | Cobalamin biosynthesis protein CobC. | 0.798 |