node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO58373.1 | AAO58374.1 | PSPTO_4945 | PSPTO_4946 | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | Conserved protein of unknown function; See PMID:20190049 for expression data. | 0.842 |
AAO58373.1 | guaA | PSPTO_4945 | PSPTO_1450 | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.521 |
AAO58373.1 | hfq | PSPTO_4945 | PSPTO_4942 | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.661 |
AAO58373.1 | miaA | PSPTO_4945 | PSPTO_4943 | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.901 |
AAO58373.1 | mutL | PSPTO_4945 | PSPTO_4944 | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.889 |
AAO58373.1 | nnrD | PSPTO_4945 | PSPTO_4947 | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] | 0.874 |
AAO58374.1 | AAO58373.1 | PSPTO_4946 | PSPTO_4945 | Conserved protein of unknown function; See PMID:20190049 for expression data. | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | 0.842 |
AAO58374.1 | hfq | PSPTO_4946 | PSPTO_4942 | Conserved protein of unknown function; See PMID:20190049 for expression data. | Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.580 |
AAO58374.1 | miaA | PSPTO_4946 | PSPTO_4943 | Conserved protein of unknown function; See PMID:20190049 for expression data. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.874 |
AAO58374.1 | mutL | PSPTO_4946 | PSPTO_4944 | Conserved protein of unknown function; See PMID:20190049 for expression data. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.778 |
AAO58374.1 | nnrD | PSPTO_4946 | PSPTO_4947 | Conserved protein of unknown function; See PMID:20190049 for expression data. | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] | 0.935 |
AAO58374.1 | polI | PSPTO_4946 | PSPTO_0344 | Conserved protein of unknown function; See PMID:20190049 for expression data. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.621 |
dnaN | mutL | PSPTO_0002 | PSPTO_4944 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.943 |
dnaN | mutS | PSPTO_0002 | PSPTO_4058 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.975 |
dnaN | polI | PSPTO_0002 | PSPTO_0344 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
dnaN | recA | PSPTO_0002 | PSPTO_4033 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.833 |
guaA | AAO58373.1 | PSPTO_1450 | PSPTO_4945 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | N-acetylmuramoyl-L-alanine amidase, family 3; See PMID:20190049 for expression data. | 0.521 |
guaA | hfq | PSPTO_1450 | PSPTO_4942 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.424 |
guaA | miaA | PSPTO_1450 | PSPTO_4943 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.431 |
guaA | mutL | PSPTO_1450 | PSPTO_4944 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.729 |