Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
panE-2
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
 
  
 0.941
ilvE
Branched-chain amino acid aminotransferase; Identified by match to TIGR protein family HMM TIGR01121; see PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01121.
    
 0.936
panE-1
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.928
ilvD
Dihydroxy-acid dehydratase; Similar to SP:P05791; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to SP:P05791, identified by sequence similarity, putative; Belongs to the IlvD/Edd family.
     
 0.921
birA
birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
  
 0.858
folK-2
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; See PMID:20190049 for expression data; similar to GP:3970811, and SP:P26281; identified by sequence similarity; putative.
 
  
 0.856
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.760
nadC
Nicotinate-nucleotide pyrophosphorylase; See PMID:20190049 for expression data; Belongs to the NadC/ModD family.
     0.756
pgi
Glucose-6-phosphate isomerase; Identified by match to PFAM protein family HMM PF00342; see PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00342.
     
 0.750
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.