Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
phhAPhenylalanine-4-hydroxylase; Identified by match to TIGR protein family HMM TIGR01270. (265 aa)    
Predicted Functional Partners:
phhB
Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
 
 0.999
hppD
4-hydroxyphenylpyruvate dioxygenase; Identified by match to PFAM protein family HMM PF00903; see PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00903.
 
  
 0.960
hisC
Histidinol-phosphate aminotransferase; Identified by match to TIGR protein family HMM TIGR01265; see PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01265; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.960
tyrB
Aromatic-amino-acid aminotransferase; See PMID:20190049 for expression data; similar to GP:13364513, and SP:P04693; identified by sequence similarity; putative.
  
 
 0.954
aspC
Aspartate aminotransferase; See PMID:20190049 for expression data.
  
 
 0.948
pheA
Chorismate mutase/prephenate dehydratase; See PMID:20190049 for expression data.
    
 0.930
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
 
  
 0.921
AAO55268.1
Prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase family protein; See PMID:20190049 for expression data.
    
 0.915
aspB
Aspartate aminotransferase; Similar to SP:P53001; identified by sequence similarity; putative.
   
 
 0.907
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.904
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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