STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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[Homology]
Score
sucCsuccinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
sdhA
Succinate dehydrogenase, flavoprotein subunit; Similar to SP:P10444, GB:D12485, GB:M57736, SP:P22413, PID:189650, PID:219944, and PID:219945; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to SP:P10444, GB:D12485, GB:M57736, SP:P22413, PID:189650, PID:219944, and PID:219945, identified by sequence similarity, putative; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.991
sdhB
Succinate dehydrogenase, iron-sulfur protein; Similar to SP:P07014, GB:L05004, and PID:152957; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to SP:P07014, GB:L05004, and PID:152957, identified by sequence similarity, putative.
 
 0.990
sdhC
Succinate dehydrogenase, cytochrome b556 subunit; See PMID:20190049 for expression data; similar to GP:9947544, and SP:P10446; identified by sequence similarity; putative.
  
 
 0.988
AAO55712.1
Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.986
sucB
2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.985
sucA
2-oxoglutarate dehydrogenase, E1 component; Identified by match to PFAM protein family HMM PF02779; see PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF02779.
 
 
 0.973
AAO54875.1
Conserved hypothetical protein; Similar to GP:15981196; identified by sequence similarity; putative.
  
 0.972
nuoCD
NADH dehydrogenase I, C/D subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
  
 
 0.962
aceF
Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.942
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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