STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1519 aa)    
Predicted Functional Partners:
CDC45
Cell division cycle 45.
   
 0.999
BRCA1
BRCA1 DNA repair associated.
   
 0.998
MCM5
Minichromosome maintenance complex component 5.
   
 0.997
BARD1
BRCA1 associated RING domain 1.
   
 0.997
MCM3
Minichromosome maintenance complex component 3.
   
 0.995
TP53BP1
Tumor protein p53 binding protein 1.
    
 
 0.993
WRN
WRN RecQ like helicase.
   
 0.993
ATR
ATR serine/threonine kinase.
    
 0.986
BRIP1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.981
GINS1
GINS complex subunit 1.
   
 0.977
Your Current Organism:
Aquila chrysaetos
NCBI taxonomy Id: 223781
Other names: A. chrysaetos chrysaetos, Aquila chrysaetos chrysaetos
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.