STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRAK4Interleukin 1 receptor associated kinase 4. (464 aa)    
Predicted Functional Partners:
MYD88
MYD88 innate immune signal transduction adaptor.
   
 0.996
IRAK2
Interleukin 1 receptor associated kinase 2.
   
0.994
TIRAP
TIR domain containing adaptor protein.
    
 0.952
TLR4
Toll like receptor 4.
   
 0.948
TRAF6
TNF receptor associated factor 6.
   
 0.947
PELI1
Pellino E3 ubiquitin protein ligase 1.
    
 0.943
IRF7
Interferon regulatory factor 7.
   
 0.939
TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1.
   
 0.932
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
  
 
0.929
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.926
Your Current Organism:
Aquila chrysaetos
NCBI taxonomy Id: 223781
Other names: A. chrysaetos chrysaetos, Aquila chrysaetos chrysaetos
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.