STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFP82180.1Hypothetical protein. (167 aa)    
Predicted Functional Partners:
SFP88595.1
ATP-dependent DNA helicase RecQ.
  
 
 0.842
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.833
SFP51009.1
PAS domain S-box-containing protein.
   
 0.827
SFP54714.1
Serine/threonine protein phosphatase PrpC.
  
 
 0.794
SFP32945.1
Response regulator receiver domain-containing protein.
  
 0.793
SFP03076.1
ABC-type nitrate/sulfonate/bicarbonate transport system, substrate-binding protein.
   
 0.792
SFP03142.1
Polar amino acid transport system substrate-binding protein.
   
 0.792
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.778
SFP96620.1
Signal transduction histidine kinase.
  
 0.758
SFP93079.1
Signal transduction histidine kinase.
    
  0.747
Your Current Organism:
Hydrogenimonas thermophila
NCBI taxonomy Id: 223786
Other names: ATCC BAA-737, H. thermophila, Hydrogenimonas thermophila Takai et al. 2004, JCM 11971, strain EP1-55-1%
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.