STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dacASerine-type d-ala-d-ala carboxypeptidase (penicillin-binding protein 5/6); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors (443 aa)    
Predicted Functional Partners:
dacC
Serine-type d-ala-d-ala carboxypeptidase/endopeptidase (penicillin-binding protein 4); Catalyzes DD-carboxypeptidase and transpeptidation reactions
    
 0.984
pbpA
Transpeptidase (penicillin-binding protein 2a); Uncharacterized protein YqgF; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme
 
 0.915
yodJ
Putative carboxypeptidase YodJ; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme
    
 0.902
pbpF
Penicillin-binding protein 2c required for spore germination; Cell wall formation. May be involved in outgrowth of the germinated spore or it could function in the synthesis of the germ cell wall
     
 0.901
ponA
Peptidoglycan glycosyltransferase (penicillin-binding proteins 1a and 1b); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits)
  
  
 0.900
metQ
Methionine abc transporter, substrate binding lipoprotein; Part of the ABC transporter complex MetNPQ involved in methionine import. Binds the methionine and transfers it to the membrane-bound permease. It has also been shown to be involved in methionine sulfoxide transport (Probable)
      
 0.882
dacF
Serine-type d-ala-d-ala carboxypeptidase (penicillin-binding protein 5/6); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
  
  
0.865
dacB
Serine-type d-ala-d-ala carboxypeptidase (penicillin-binding protein 5/6); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Required specifically for the synthesis of the spore form of peptidoglycan (cortex)
 
  
 
0.856
pbpH
Penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall; Involved in the polymerization of peptidoglycan. Plays a redundant role with PBP2a in determining the rod shape of the cell during vegetative growth and spore outgrowth
 
 
 0.836
amiE
Amidase hydrolyzing n-acetylmuramyl-l-ala bond of murnac peptides; Involved in muropeptide recycling. Hydrolyzes the amide bond between N-acetylmuramic acid (MurNAc) and the L-alanine residue of the stem peptide. Cannot hydrolyze muropeptides containing N- acetylglucosamine (GlcNAc) at the non-reducing end
     
 0.827
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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