STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yaaQConserved hypothetical protein; Binds cyclic di-AMP (c-di-AMP) and is probably involved in c- di-AMP-mediated signaling pathways. In vitro, can also bind cyclic GMP- AMP (3'3'-cGAMP), with lower affinity, but not c-di-GMP or 2'3'-cGAMP. (109 aa)    
Predicted Functional Partners:
yaaR
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
 
    0.980
holB
DNA polymerase III delta' subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.
  
    0.921
pstA
Phosphate ABC transporter (permease); Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
      
 0.912
ktrA
Potassium uptake protein; Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.
      
 0.907
yaaT
Conserved hypothetical protein; Essential for the phosphorelay during initiation of sporulation. May control the level of phosphorylated spo0A through spo0E activity during sporulation.
  
    0.885
ydaO
Putative metabolite transporter; High-affinity potassium transporter.
      
 0.879
carA
Arginine-specific carbamoyl-phosphate synthetase (small subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
      
 0.879
ktrC
Potassium uptake protein; Catalytic subunit of the KtrCD potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.
   
  
 0.871
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
 
  
 0.856
dnaH
Subunit of the DNA replication complex; Involved in initiation control of chromosome replication.
  
    0.818
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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