STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vegConserved hypothetical protein; Stimulates biofilm formation via transcriptional activation of extracellular matrix genes. Acts by repressing SinR activity, independently of the SinI, SlrA and SlrR pathways. Could also be involved in the regulation of other genes during biofilm and spore formation. (86 aa)    
Predicted Functional Partners:
mstX
Atypical membrane-integrating protein (Mistic protein); Chaperone that facilitates the production and integration of integral membrane proteins into the bacterial lipid bilayer.
      
 0.890
yugP
Putative metal-dependent protease/peptidase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
   
 0.767
abbA
Regulator of AbrB repressor; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator.
   
  
 0.754
purR
Transcriptional regulator of the purine biosynthesis operon; Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
    0.715
cggR
Transcriptional regulator of gapA; In the absence of glucose, represses the transcription of the gapA operon, which encodes five key glycolytic enzymes. Binds specifically to the cggR-gapA promoter region and blocks the progression of the RNA polymerase, leading to the arrest of the transcription; Belongs to the SorC transcriptional regulatory family.
  
     0.684
sspF
Small acid-soluble spore protein (alpha/beta-type SASP); May play some important role in either sporulation or the dormant spore.
 
    0.667
yybS
Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
  
    0.525
yabG
Sporulation-specific protease; Cleaves the spore coat proteins SpoIVA and SafA. May cooperate with tgl to mediate the temperature-dependent cross-linking of coat proteins like GerQ.
  
    0.518
divIVA
Cell-division initiation protein; May act as a pilot protein, directing MinCD to the polar septation sites or by inhibiting MinCD at the midcell site of division. Required for polar localization of the chromosome during sporulation.
  
     0.497
yunD
Putative nuclease/nucleotidase/phosphoesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
     0.432
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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