STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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spoVTAbrb family transcriptional regulator, stage v sporulation protein t; Transcriptional factor that regulates positively or negatively the expression of a large number of forespore-specific sigma G-dependent genes. May provide a mechanism of feedback control that is important for forespore development . SpoVT levels during spore formation have a major impact on the germination and the resistance of the resultant spores (178 aa)    
Predicted Functional Partners:
spoIIID
Putative deor family transcriptional regulator, stage iii sporulation protein d; This protein regulates the transcription of sigK, which encodes mother cell chamber RNA polymerase sigma-factor (sigma K)
  
   
 0.963
sigG
Rna polymerase sporulation-specific sigma factor (sigma-g); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released . This sigma factor is responsible for the expression of sporulation specific genes in the forespore
  
   
 0.946
yabN
Putative fusion methylase and nucleotide pyrophosphohydrolase; Uncharacterized protein YabN; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
      0.917
gpr
Germination protease; Initiates the degradation of small, acid-soluble proteins during spore germination
  
   
 0.908
spoVAD
Stage V sporulation protein AD; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process
  
   
 0.902
tepA
Translocation-enhancing protein tepa; Required for efficient translocation of pre-proteins across the membrane
  
   
 0.899
sigF
Rna polymerase sporulation-specific sigma factor (sigma-f); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes . Interaction with SpoIIAB inhibits sigma-F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. Responsible for expression of csfB (the anti-sigma-G factor Gin)
  
   
 0.891
yabP
Spore protein involved in the shaping of the spore coat; Required for sporulation
 
     0.882
spo0A
Two-component system, response regulator, stage 0 sporulation protein a; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box)
  
   
 0.882
spoIVA
Morphogenetic stage iv sporulation protein; ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM
  
   
 0.872
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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