STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
feuAIron hydroxamate-binding lipoprotein; Involved in the uptake of iron. Belongs to the bacterial solute-binding protein 8 family. (317 aa)    
Predicted Functional Partners:
feuC
Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane.
 
 
 0.997
feuB
Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane.
 
 
 0.996
ybbA
Putative iron-chelator esterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
 
  
 0.959
yusV
iron(III)-siderophore transporter (ATP binding component); Provides the ATPase subunit for at least 2 ABC transporter complexes; YfiYZ/YfhA/YusV involved in import of the iron-hydroxamate siderophores schizokinen, arthrobactin and corprogen (Probable), and FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin (Probable). Probably responsible for energy coupling to the transport system (By similarity).
 
 
 0.933
fhuC
Ferrichrome ABC transporter (ATP-binding protein); Part of the ABC transporter complex FhuBGCD involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily. Iron (Fe3+)- hydroxamate importer (TC 3.A.1.14.7) family.
 
 
 0.932
btr
HTH-type transcriptional activator Btr; In iron-limited conditions, activates expression of the feuABCybbA operon, which encodes the bacillibactin uptake system. Acts by binding directly to a conserved direct repeat element upstream of the feuA promoter. Activity is increased in the presence of bacillibactin.
 
  
0.910
besA
Bacillibactin trilactone hydrolase; Catalyzes the hydrolysis of the trilactone cycle of ferri- bacillibactin (ferri-BB) complex, leading to the formation of bacillibactin monomers and to cytosolic iron release, thus making iron available for metabolic use. Can also hydrolyze bacillibactin (BB), however the catalytic efficiency for ferri-BB hydrolysis is much higher than for BB.
 
  
 0.902
dhbA
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.895
yfmF
Iron-dicitrate ABC transporter (ATP-binding protein); Part of the ABC transporter complex YfmCDEF involved in citrate-dependent Fe(3+) import. Responsible for energy coupling to the transport system (Probable).
 
 
 0.888
fhuD
Ferrichrome ABC transporter (ferrichrome-binding lipoprotein); Part of the ABC transporter complex FhuCBGD involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of ferrichrome and coprogen.
  
  
0.865
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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