STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
skfBSynthesis of sporulation killing factor A; Catalyzes the formation of the thioether bond required for production of the sporulation killing factor (SKF) from SkfA. Forms the cysteine-methionine thioether bond found in SKF; the acceptor amino acid can be hydrophobic, aromatic or a small hydrophilic amino acid but not a larger hydrophilic amino acid, i.e. Met=Ala, Phe, Leu, Tyr>Asn, Ser>>Gln, Glu, Lys. The relative position of Cys and Met in the substrate cannot be inverted, in vitro the thioether bond cannot be made in the absence of the SkfA propeptide, suggesting this is the first rea [...] (410 aa)    
Predicted Functional Partners:
skfC
Sporulation killing factor biosynthesis and export; Required for production of the bacteriocin SkfA.
  
  
 0.995
skfE
Sporulation killing factor biosynthesis and export; Probably part of the ABC transporter SkfEF involved in the export of the bacteriocin SKF. Probably responsible for energy coupling to the transport system.
 
  
 0.990
skfH
Sibling killing effect; Required for production of the bacteriocin SkfA.
 
  
 0.988
skfA
Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...]
  
  
 0.986
skfG
Sporulation killing factor biosynthesis and export; Required for production of the bacteriocin SkfA.
  
  
 0.976
skfF
Sporulation killing factor biosynthesis and export; Probably part of the ABC transporter SkfEF involved in the export of the bacteriocin SKF. Probably responsible for the translocation of bacteriocin SkfA across the membrane.
  
  
 0.969
yydG
Putative AdoMet radical enzyme; Required for production of the modified peptide YydF (Probable). May activate a metalloenzyme (Potential).
   
  
 0.740
sdpR
Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation.
   
  
 0.685
asnH
Asparagine synthetase (glutamine-hydrolyzing); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the asparagine synthetase family.
  
    0.639
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate (By similarity). Required for both nitrate assimilation and respiration.
     
 0.566
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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