STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
glnLTwo-component response regulator [GlnJ] for glutamine utilisation; Member of the two-component regulatory system GlnL/GlnK that positively regulates the expression of the glsA-glnT operon in response to glutamine. GlnL binds the promoter region of glsA-glnT in vitro. (314 aa)    
Predicted Functional Partners:
glnJ
Two-component sensor histidine kinase [GlnL] for glutamine degradation; Member of the two-component regulatory system GlnK/GlnL that positively regulates the expression of the glsA-glnT operon in response to glutamine. It seems that autophosphorylated GlnK transfers a phosphoryl group to GlnL, which positively regulates the expression of the glsA-glnT operon. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation.
 
 0.999
glsA
Glutaminase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
  
  
 0.848
glnT
Glutamine transporter; Probably functions as a sodium/glutamine symporter for glutamine uptake; Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
  
  
 0.771
ymfC
Putative transcriptional regulator (GntR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator.
   
  
 0.696
ywnA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
      
 0.620
yesM
Two-component sensor histidine kinase [YesN]; Member of the two-component regulatory system YesM/YesN. Probably activates YesN by phosphorylation.
      
 0.572
ydeB
Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the CarD family.
      
 0.568
cheV
Coupling protein and response regulator for CheA activity in response to attractants (chemotaxis); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl- accepting chemoreceptors to the central two-component kinase CheA; they are both necessary for efficient chemotaxis. Moreover, CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B.subtilis chemotaxis.
 
 
 0.562
lytR
Membrane-bound transcriptional regulator; May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).
   
  
 0.469
ycbC
5-dehydro-4-deoxyglucarate dehydratase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the DapA family.
  
    0.434
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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