STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ycbD2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase); Catalyzes the NAD(P)(+)-dependent oxidation of alpha- ketoglutaric semialdehyde (alphaKGSA) to alpha-ketoglutarate. Prefers NADP(+) to NAD(+) as a cosubstrate. In vitro, can also use various aldehydes. (488 aa)    
Predicted Functional Partners:
ycbC
5-dehydro-4-deoxyglucarate dehydratase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the DapA family.
  
 
 0.950
putM
Proline dehydrogenase 1; Converts proline to delta-1-pyrroline-5-carboxylate.
 
 
 0.911
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
    
 0.902
glsA
Glutaminase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
  
 
 0.886
ysmA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
      
 0.852
gudP
Glucarate transporter; Uptake of D-glucarate; Belongs to the major facilitator superfamily. Phthalate permease family.
  
    0.776
yneP
acyl-CoA thioesterase; Has acyl-CoA thioesterase activity.
      
 0.763
pucH
Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
  
  
 0.695
gmuG
Exported mannan endo-1,4-beta-mannosidase; Involved in the degradation of glucomannan. Catalyzes the endo hydrolysis of beta-1,4-linked mannan, galactomannan and glucomannan; Belongs to the glycosyl hydrolase 26 family.
   
  
 0.683
putB
Proline oxidase; Converts proline to delta-1-pyrroline-5-carboxylate. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source.
 
 
 0.592
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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